2i6e

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(New page: 200px<br /><applet load="2i6e" size="350" color="white" frame="true" align="right" spinBox="true" caption="2i6e, resolution 2.50&Aring;" /> '''Crystal structure of...)
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[[Image:2i6e.gif|left|200px]]<br /><applet load="2i6e" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i6e, resolution 2.50&Aring;" />
 
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'''Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178'''<br />
 
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==Overview==
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==Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178==
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ABSTRACT: BACKGROUND: Pfam is a comprehensive collection of protein, domains and families, with a range of well-established information, including genome annotation. Pfam has two large series of functionally, uncharacterized families, known as Domains of Unknown Function (DUFs) and, Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of, two proteins from Deinococcus radiodurans and Streptomyces coelicolor, belonging to Pfam protein family DUF178 (ID: PF02621) have been determined, using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on, the structure, we have identified the putative function for this family of, protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably, similar to Pfam family DUF191 suggesting that the sequence-based, classification alone may not be sufficient to classify proteins into Pfam, families.
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<StructureSection load='2i6e' size='340' side='right'caption='[[2i6e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I6E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6e OCA], [https://pdbe.org/2i6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i6e RCSB], [https://www.ebi.ac.uk/pdbsum/2i6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i6e ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2i6e TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i6e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i6e ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.
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==About this Structure==
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X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family.,Tyagi R, Burley SK, Swaminathan S BMC Struct Biol. 2007 Oct 1;7:62. PMID:17908300<ref>PMID:17908300</ref>
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2I6E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6E OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7(1):62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]
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</div>
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[[Category: Deinococcus radiodurans]]
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<div class="pdbe-citations 2i6e" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Burley, S.K.]]
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<references/>
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[[Category: Kumaran, D.]]
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__TOC__
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[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
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</StructureSection>
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[[Category: Swaminathan, S.]]
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[[Category: Large Structures]]
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[[Category: Tyagi, R.]]
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[[Category: Burley SK]]
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[[Category: SO4]]
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[[Category: Kumaran D]]
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[[Category: 10093b]]
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[[Category: Swaminathan S]]
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[[Category: hypothetical protein]]
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[[Category: Tyagi R]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: pfam:duf178]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomics]]
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[[Category: unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:48:56 2008''
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Current revision

Crystal structure of protein DR0370 from Deinococcus radiodurans, Pfam DUF178

PDB ID 2i6e

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