2l37

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:16, 30 October 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2l37.jpg|left|200px]]
 
-
<!--
+
==3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)==
-
The line below this paragraph, containing "STRUCTURE_2l37", creates the "Structure Box" on the page.
+
<StructureSection load='2l37' size='340' side='right'caption='[[2l37]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2l37]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Luffa_aegyptiaca Luffa aegyptiaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L37 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l37 OCA], [https://pdbe.org/2l37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l37 RCSB], [https://www.ebi.ac.uk/pdbsum/2l37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l37 ProSAT]</span></td></tr>
-
{{STRUCTURE_2l37| PDB=2l37 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RIP1_LUFAE RIP1_LUFAE] Inhibits protein synthesis in animal cells.<ref>PMID:12948831</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Luffin P1, the smallest ribosome-inactivating peptide from the seeds of Luffa cylindrica was found to have anti-HIV-1 activity in HIV-1 infected C8166 T-cell lines and be able to bind with HIV Rev Response Element. Nuclear magnetic resonance spectroscopy revealed that the Luffin P1 comprises a helix-loop-helix motif, with the two alpha helices tightly associated by two disulfide bonds. Based on our findings, we conclude that unlike the well-studied ribosome-inactivating proteins, which exert their action through N-glycosidase activities, Luffin P1 demonstrates a novel inactivation mechanism probably through the charge complementation with viral or cellular proteins. Our work also provides a new scaffold for the design of novel inhibitors from a simple helical motif.
-
===3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)===
+
Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrica).,Ng YM, Yang Y, Sze KH, Zhang X, Zheng YT, Shaw PC J Struct Biol. 2010 Dec 31. PMID:21195767<ref>PMID:21195767</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2l37" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_21195767}}, adds the Publication Abstract to the page
+
*[[Ribosome inactivating protein 3D structures|Ribosome inactivating protein 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 21195767 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21195767}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[2l37]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Luffa_aegyptiaca Luffa aegyptiaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L37 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:21195767</ref><references group="xtra"/>
+
[[Category: Luffa aegyptiaca]]
[[Category: Luffa aegyptiaca]]
-
[[Category: RRNA N-glycosylase]]
+
[[Category: Ng YM]]
-
[[Category: Ng, Y M.]]
+
[[Category: Shaw PC]]
-
[[Category: Shaw, P C.]]
+
[[Category: Sze KH]]
-
[[Category: Sze, K H.]]
+
[[Category: Yang Y]]
-
[[Category: Yang, Y.]]
+
[[Category: Zhang X]]
-
[[Category: Zhang, X.]]
+
[[Category: Zheng YT]]
-
[[Category: Zheng, Y T.]]
+

Current revision

3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)

PDB ID 2l37

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l37"
Personal tools