2mp1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2mp1 is ON HOLD Authors: Veldkamp, C.T., Peterson, F.C., Gabel-Eissens, S.J., Gillitzer, M.L. Description: Solution structure of the human chemokin...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of the human chemokine CCL19== | |
| + | <StructureSection load='2mp1' size='340' side='right'caption='[[2mp1]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mp1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MP1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp1 OCA], [https://pdbe.org/2mp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mp1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mp1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CCL19_HUMAN CCL19_HUMAN] May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<ref>PMID:9498785</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive. Implications for the mechanism of PSGL-1's enhancement of resting T-cell recruitment are discussed. | ||
| - | + | Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.,Veldkamp CT, Kiermaier E, Gabel-Eissens SJ, Gillitzer ML, Lippner DR, DiSilvio FA, Mueller CJ, Wantuch PL, Chaffee GR, Famiglietti MW, Zgoba DM, Bailey AA, Bah Y, Engebretson SJ, Graupner DR, Lackner ER, LaRosa VD, Medeiros T, Olson ML, Phillips AJ, Pyles H, Richard AM, Schoeller SJ, Touzeau B, Williams LG, Sixt M, Peterson FC Biochemistry. 2015 Jul 14;54(27):4163-6. doi: 10.1021/acs.biochem.5b00560. Epub, 2015 Jul 6. PMID:26115234<ref>PMID:26115234</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2mp1" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gabel-Eissens SJ]] | ||
| + | [[Category: Gillitzer ML]] | ||
| + | [[Category: Peterson FC]] | ||
| + | [[Category: Veldkamp CT]] | ||
Current revision
Solution structure of the human chemokine CCL19
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