We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

3bhd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:48, 30 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3bhd.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of human thiamine triphosphatase (THTPA)==
-
|PDB= 3bhd |SIZE=350|CAPTION= <scene name='initialview01'>3bhd</scene>, resolution 1.50&Aring;
+
<StructureSection load='3bhd' size='340' side='right'caption='[[3bhd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
<table><tr><td colspan='2'>[[3bhd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BHD FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
|GENE= THTPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bhd OCA], [https://pdbe.org/3bhd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bhd RCSB], [https://www.ebi.ac.uk/pdbsum/3bhd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bhd ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bhd OCA], [http://www.ebi.ac.uk/pdbsum/3bhd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bhd RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/THTPA_HUMAN THTPA_HUMAN] Hydrolase highly specific for thiamine triphosphate (ThTP).
-
 
+
== Evolutionary Conservation ==
-
'''Crystal structure of human thiamine triphosphatase (THTPA)'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/3bhd_consurf.spt"</scriptWhenChecked>
-
3BHD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHD OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bhd ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Thiamine-triphosphatase]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Berglund H]]
-
[[Category: Berg, S Van den.]]
+
[[Category: Busam RD]]
-
[[Category: Berglund, H.]]
+
[[Category: Collins R]]
-
[[Category: Busam, R D.]]
+
[[Category: Dahlgren LG]]
-
[[Category: Collins, R.]]
+
[[Category: Edwards AM]]
-
[[Category: Dahlgren, L G.]]
+
[[Category: Flodin S]]
-
[[Category: Edwards, A M.]]
+
[[Category: Flores A]]
-
[[Category: Flodin, S.]]
+
[[Category: Graslund S]]
-
[[Category: Flores, A.]]
+
[[Category: Hallberg BM]]
-
[[Category: Graslund, S.]]
+
[[Category: Hammarstrom M]]
-
[[Category: Hallberg, B M.]]
+
[[Category: Herman MD]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Johansson A]]
-
[[Category: Herman, M D.]]
+
[[Category: Johansson I]]
-
[[Category: Johansson, A.]]
+
[[Category: Kallas A]]
-
[[Category: Johansson, I.]]
+
[[Category: Karlberg T]]
-
[[Category: Kallas, A.]]
+
[[Category: Kotenyova T]]
-
[[Category: Karlberg, T.]]
+
[[Category: Lehtio L]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Moche M]]
-
[[Category: Lehtio, L.]]
+
[[Category: Nilsson ME]]
-
[[Category: Moche, M.]]
+
[[Category: Nordlund P]]
-
[[Category: Nilsson, M E.]]
+
[[Category: Nyman T]]
-
[[Category: Nordlund, P.]]
+
[[Category: Persson C]]
-
[[Category: Nyman, T.]]
+
[[Category: Sagemark J]]
-
[[Category: Persson, C.]]
+
[[Category: Sundstrom M]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Svensson L]]
-
[[Category: Sagemark, J.]]
+
[[Category: Thorsell AG]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Tresaugues L]]
-
[[Category: Svensson, L.]]
+
[[Category: Van den Berg S]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Weigelt J]]
-
[[Category: Tresaugues, L.]]
+
[[Category: Welin M]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Welin, M.]]
+
-
[[Category: acetylation]]
+
-
[[Category: cyth domain]]
+
-
[[Category: cytoplasm]]
+
-
[[Category: hydrolase]]
+
-
[[Category: phosphatase]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:13 2008''
+

Current revision

Crystal structure of human thiamine triphosphatase (THTPA)

PDB ID 3bhd

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bhd"
Personal tools