3gbw

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{{Seed}}
 
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[[Image:3gbw.png|left|200px]]
 
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==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==
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The line below this paragraph, containing "STRUCTURE_3gbw", creates the "Structure Box" on the page.
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<StructureSection load='3gbw' size='340' side='right'caption='[[3gbw]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3gbw| PDB=3gbw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [https://pdbe.org/3gbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [https://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbw ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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PHR [PAM (protein associated with Myc)-HIW (Highwire)-RPM-1 (regulator of presynaptic morphology 1)] proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterized by the presence of two PHR domains near the N-terminus, which are essential for proper localization and function. Structures of both the first and second PHR domains of Mus musculus (mouse) Phr1 (MYC binding protein 2, Mycbp2) have been determined, revealing a novel beta sandwich fold composed of 11 antiparallel beta-strands. Conserved loops decorate the apical side of the first PHR domain (MmPHR1), yielding a distinct conserved surface feature. The surface of the second PHR domain (MmPHR2), in contrast, lacks significant conservation. Importantly, the structure of MmPHR1 provides insights into a loss-of-function mutation, Gly1092--&gt;Glu, observed in the Caenorhabditis elegans ortholog RPM-1.
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===Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)===
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Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092--&gt;Glu) of the C. elegans ortholog RPM-1.,Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK J Mol Biol. 2010 Apr 9;397(4):883-92. Epub 2010 Feb 13. PMID:20156452<ref>PMID:20156452</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3gbw" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20156452}}, adds the Publication Abstract to the page
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20156452 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20156452}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3GBW is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].
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[[Category: Atwell S]]
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[[Category: Bain KT]]
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==Reference==
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[[Category: Burley SK]]
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<ref group="xtra">PMID:20156452</ref><references group="xtra"/>
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[[Category: Klemke RL]]
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[[Category: Mus musculus]]
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[[Category: Miller SA]]
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[[Category: Atwell, S.]]
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[[Category: Ozyurt SA]]
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[[Category: Bain, K T.]]
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[[Category: Rutter ME]]
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[[Category: Burley, S K.]]
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[[Category: Sampathkumar P]]
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[[Category: Klemke, R L.]]
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[[Category: Sauder JM]]
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[[Category: Miller, S A.]]
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[[Category: Tarun G]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Wasserman SR]]
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[[Category: Ozyurt, S A.]]
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[[Category: Rutter, M E.]]
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[[Category: Sampathkumar, P.]]
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[[Category: Sauder, J M.]]
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[[Category: Tarun, G.]]
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[[Category: Wasserman, S R.]]
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[[Category: Alternative splicing]]
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[[Category: Ligase]]
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[[Category: Metal-binding]]
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[[Category: Myc-binding protein 2]]
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[[Category: Mycbp2]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nucleus]]
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[[Category: Nysgxrc]]
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[[Category: Pam]]
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[[Category: Phosphoprotein]]
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[[Category: Phr domain]]
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[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]
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[[Category: Protein associated with myc]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Rpm-1]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:09:37 2010''
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Current revision

Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)

PDB ID 3gbw

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