3nvn

From Proteopedia

(Difference between revisions)

Current revision

Molecular mechanism of guidance cue recognition

Structural highlights

3nvn is a 2 chain structure with sequence from Ectromelia virus and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.26Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SEMA_ECTVM Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Repulsive signaling by Semaphorins and Plexins is crucial for the development and homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox virus. We report the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1. Both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers, in which the Semaphorin and PlexinC1 beta propellers interact in an edge-on, orthogonal orientation. Both binding interfaces are dominated by the insertion of the Semaphorin's 4c-4d loop into a deep groove in blade 3 of the PlexinC1 propeller. A39R appears to achieve Sema7A mimicry by preserving key Plexin-binding determinants seen in the mammalian Sema7A complex that have evolved to achieve higher affinity binding to the host-derived PlexinC1. The complex structures support a conserved Semaphorin-Plexin recognition mode and suggest that Plexins are activated by dimerization.

Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.,Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X Cell. 2010 Sep 3;142(5):749-61. Epub 2010 Aug 19. PMID:20727575^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Walzer T, Galibert L, Comeau MR, De Smedt T. Plexin C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin-mediated adhesion and chemokine-induced migration. J Immunol. 2005 Jan 1;174(1):51-9. PMID:15611227
↑ Walzer T, Galibert L, De Smedt T. Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils. Eur J Immunol. 2005 Feb;35(2):391-8. PMID:15657950 doi:http://dx.doi.org/10.1002/eji.200425669
↑ Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X. Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell. 2010 Sep 3;142(5):749-61. Epub 2010 Aug 19. PMID:20727575 doi:10.1016/j.cell.2010.07.040

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nvn"

@@ Line 1: / Line 1: @@
 ==Molecular mechanism of guidance cue recognition==
-<StructureSection load='3nvn' size='340' side='right' caption='[[3nvn]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
+<StructureSection load='3nvn' size='340' side='right'caption='[[3nvn]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3nvn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ectromelia_mousepox_virus Ectromelia mousepox virus] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NVN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3nvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ectromelia_virus Ectromelia virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nvx|3nvx]], [[3nvq|3nvq]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEMA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12643 Ectromelia mousepox virus]), PLXNC1, VESPR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvn OCA], [https://pdbe.org/3nvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nvn RCSB], [https://www.ebi.ac.uk/pdbsum/3nvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nvn ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nvn OCA], [http://pdbe.org/3nvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nvn RCSB], [http://www.ebi.ac.uk/pdbsum/3nvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nvn ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SEMA_ECTVM SEMA_ECTVM]] Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection.<ref>PMID:15611227</ref> <ref>PMID:15657950</ref>  [[http://www.uniprot.org/uniprot/PLXC1_HUMAN PLXC1_HUMAN]] Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).<ref>PMID:20727575</ref>
+[https://www.uniprot.org/uniprot/SEMA_ECTVM SEMA_ECTVM] Acts as a semaphorin-like protein and binds to host plexin C1 receptor. May alter the movement of plexin C1-expressing cells including dendritic cells, monocytes, or granulocytes in the proximity of infected cells. May also regulate host cell cytoskeleton of neighboring cells to improve viral infection.<ref>PMID:15611227</ref> <ref>PMID:15657950</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 16: / Line 15: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/3nvn_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 33: / Line 32: @@
 ==See Also==
 *[[Plexin|Plexin]]
+*[[Plexin 3D structures|Plexin 3D structures]]
 *[[Semaphorin|Semaphorin]]
+*[[Semaphorin 3D structures|Semaphorin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ectromelia mousepox virus]]
+[[Category: Ectromelia virus]]
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Chen, X]]
+[[Category: Large Structures]]
-[[Category: Focia, P]]
+[[Category: Chen X]]
-[[Category: Garcia, C]]
+[[Category: Focia P]]
-[[Category: He, X]]
+[[Category: Garcia C]]
-[[Category: Juo, Z]]
+[[Category: He X]]
-[[Category: Liu, H]]
+[[Category: Juo Z]]
-[[Category: Shim, A]]
+[[Category: Liu H]]
-[[Category: Beta-propeller]]
+[[Category: Shim A]]
-[[Category: Signaling]]
-[[Category: Viral protein-signaling protein complex]]

3nvn

From Proteopedia

Current revision

Molecular mechanism of guidance cue recognition

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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