5vhz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:54, 30 October 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==GluA2-2xGSG1L bound to L-Quisqualate==
==GluA2-2xGSG1L bound to L-Quisqualate==
-
<StructureSection load='5vhz' size='340' side='right' caption='[[5vhz]], [[Resolution|resolution]] 8.40&Aring;' scene=''>
+
<SX load='5vhz' size='340' side='right' viewer='molstar' caption='[[5vhz]], [[Resolution|resolution]] 8.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5vhz]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VHZ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5vhz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VHZ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.4&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vhw|5vhw]], [[5vhx|5vhx]], [[5vhy|5vhy]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vhz OCA], [http://pdbe.org/5vhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vhz RCSB], [http://www.ebi.ac.uk/pdbsum/5vhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vhz ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vhz OCA], [https://pdbe.org/5vhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vhz RCSB], [https://www.ebi.ac.uk/pdbsum/5vhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vhz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
+
[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> [https://www.uniprot.org/uniprot/GSG1L_RAT GSG1L_RAT] As a component of the inner core of AMPAR complexes, modifies AMPA receptor (AMPAR) gating.<ref>PMID:22632720</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5vhz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5vhz" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
-
</StructureSection>
+
</SX>
-
[[Category: Frank, J]]
+
[[Category: Large Structures]]
-
[[Category: Grassucci, R A]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Sobolevsky, A I]]
+
[[Category: Frank J]]
-
[[Category: Twomey, E C]]
+
[[Category: Grassucci RA]]
-
[[Category: Yelshanskaya, M V]]
+
[[Category: Sobolevsky AI]]
-
[[Category: Ion channel]]
+
[[Category: Twomey EC]]
-
[[Category: Transport protein]]
+
[[Category: Yelshanskaya MV]]

Current revision

GluA2-2xGSG1L bound to L-Quisqualate

5vhz, resolution 8.40Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools