5vku

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{{Large structure}}
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==An atomic structure of the human cytomegalovirus (HCMV) capsid with its securing layer of pp150 tegument protein==
==An atomic structure of the human cytomegalovirus (HCMV) capsid with its securing layer of pp150 tegument protein==
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<StructureSection load='5vku' size='340' side='right' caption='[[5vku]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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<SX load='5vku' size='340' side='right' viewer='molstar' caption='[[5vku]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vku]] is a 62 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_cytomegalovirus_(strain_ad169) Human cytomegalovirus (strain ad169)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vku]] is a 62 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VKU FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vku OCA], [http://pdbe.org/5vku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vku RCSB], [http://www.ebi.ac.uk/pdbsum/5vku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vku ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vku OCA], [https://pdbe.org/5vku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vku RCSB], [https://www.ebi.ac.uk/pdbsum/5vku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vku ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRX1_HCMVA TRX1_HCMVA]] Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly. [[http://www.uniprot.org/uniprot/PP150_HCMVA PP150_HCMVA]] Participates in the last steps of viral maturation and release. Associates with nuclear capsids prior to DNA encapsidation and later preserves the integrity of nucleocapsids through secondary envelopment at the assembly compartment. Interacts with host CCNA2 and thereby blocks the onset of lytic gene expression to promote establishment of a quiescent state of infection in undifferentiated cells.<ref>PMID:16873276</ref> <ref>PMID:18653449</ref> <ref>PMID:21411515</ref> <ref>PMID:23966856</ref> <ref>PMID:24101496</ref> [[http://www.uniprot.org/uniprot/SCP_HCMVA SCP_HCMVA]] Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly. [[http://www.uniprot.org/uniprot/MCP_HCMVA MCP_HCMVA]] Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins. [[http://www.uniprot.org/uniprot/TRX2_HCMVA TRX2_HCMVA]] Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.
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[https://www.uniprot.org/uniprot/PP150_HCMVA PP150_HCMVA] Participates in the last steps of viral maturation and release. Associates with nuclear capsids prior to DNA encapsidation and later preserves the integrity of nucleocapsids through secondary envelopment at the assembly compartment. Interacts with host CCNA2 and thereby blocks the onset of lytic gene expression to promote establishment of a quiescent state of infection in undifferentiated cells.<ref>PMID:16873276</ref> <ref>PMID:18653449</ref> <ref>PMID:21411515</ref> <ref>PMID:23966856</ref> <ref>PMID:24101496</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Jiang, J]]
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[[Category: Human herpesvirus 5 strain AD169]]
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[[Category: Jih, J]]
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[[Category: Large Structures]]
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[[Category: Yu, X]]
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[[Category: Jiang J]]
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[[Category: Zhou, H]]
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[[Category: Jih J]]
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[[Category: Capsid]]
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[[Category: Yu X]]
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[[Category: Herpesvirus]]
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[[Category: Zhou H]]
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[[Category: Icosahedral]]
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[[Category: Tegument]]
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[[Category: Virus]]
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Current revision

An atomic structure of the human cytomegalovirus (HCMV) capsid with its securing layer of pp150 tegument protein

5vku, resolution 3.90Å

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