7n1v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 7n1v is ON HOLD Authors: Zhang, J., Cai, Y.F., Xiao, T.S., Rawson, S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Volloch, S.R., Chen, B. Descript...)
Current revision (11:36, 30 October 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7n1v is ON HOLD
+
==Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants==
 +
<StructureSection load='7n1v' size='340' side='right'caption='[[7n1v]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N1V FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n1v OCA], [https://pdbe.org/7n1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n1v RCSB], [https://www.ebi.ac.uk/pdbsum/7n1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n1v ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains in the COVID-19 pandemic. We report here cryo-EM structures of the full-length spike (S) trimers of the B.1.1.7 and B.1.351 variants, as well as their biochemical and antigenic properties. Amino acid substitutions in the B.1.1.7 protein increase the accessibility of its receptor binding domain and also the binding affinity for receptor angiotensin-converting enzyme 2 (ACE2). The enhanced receptor engagement may account for the increased transmissibility. The B.1.351 variant has evolved to reshape antigenic surfaces of the major neutralizing sites on the S protein, making it resistant to some potent neutralizing antibodies. These findings provide structural details on how SARS-CoV-2 has evolved to enhance viral fitness and immune evasion.
-
Authors: Zhang, J., Cai, Y.F., Xiao, T.S., Rawson, S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Volloch, S.R., Chen, B.
+
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants.,Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM Jr, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B Science. 2021 Jun 24. pii: science.abi9745. doi: 10.1126/science.abi9745. PMID:34168070<ref>PMID:34168070</ref>
-
Description: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Rawson, S]]
+
<div class="pdbe-citations 7n1v" style="background-color:#fffaf0;"></div>
-
[[Category: Volloch, S.R]]
+
== References ==
-
[[Category: Sterling, S.M]]
+
<references/>
-
[[Category: Peng, H.Q]]
+
__TOC__
-
[[Category: Xiao, T.S]]
+
</StructureSection>
-
[[Category: Zhang, J]]
+
[[Category: Large Structures]]
-
[[Category: Walsh Jr, R.M]]
+
[[Category: Cai YF]]
-
[[Category: Cai, Y.F]]
+
[[Category: Chen B]]
-
[[Category: Chen, B]]
+
[[Category: Peng HQ]]
 +
[[Category: Rawson S]]
 +
[[Category: Sterling SM]]
 +
[[Category: Volloch SR]]
 +
[[Category: Walsh Jr RM]]
 +
[[Category: Xiao TS]]
 +
[[Category: Zhang J]]

Current revision

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

PDB ID 7n1v

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7n1v"
Personal tools