1emr

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[[Image:1emr.png|left|200px]]
 
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{{STRUCTURE_1emr| PDB=1emr | SCENE= }}
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==CRYSTAL STRUCTURE OF HUMAN LEUKEMIA INHIBITORY FACTOR (LIF)==
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<StructureSection load='1emr' size='340' side='right'caption='[[1emr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF HUMAN LEUKEMIA INHIBITORY FACTOR (LIF)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1emr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emr OCA], [https://pdbe.org/1emr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emr RCSB], [https://www.ebi.ac.uk/pdbsum/1emr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emr ProSAT]</span></td></tr>
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[[1emr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMR OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LIF_HUMAN LIF_HUMAN] LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/1emr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1emr ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Betzel, C.]]
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[[Category: Large Structures]]
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[[Category: Hawkins, N.]]
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[[Category: Betzel C]]
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[[Category: Heath, J K.]]
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[[Category: Hawkins N]]
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[[Category: Jones, E Y.]]
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[[Category: Heath JK]]
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[[Category: Robinson, R C.]]
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[[Category: Jones EY]]
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[[Category: Samal, B.]]
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[[Category: Robinson RC]]
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[[Category: 4-helix bundle]]
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[[Category: Samal B]]
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[[Category: Gene regulation]]
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Current revision

CRYSTAL STRUCTURE OF HUMAN LEUKEMIA INHIBITORY FACTOR (LIF)

PDB ID 1emr

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