1mbg

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(New page: 200px<br /><applet load="1mbg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mbg" /> '''MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2'''<b...)
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[[Image:1mbg.jpg|left|200px]]<br /><applet load="1mbg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1mbg" />
 
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'''MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2'''<br />
 
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==Overview==
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==MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2==
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The DNA-binding domain of c-Myb consists of three imperfect tandem repeats, (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved, tryptophans in each repeat participate in forming a hydrophobic core., Comparison of the three repeat structures indicated that cavities are, found in the hydrophobic core of R2, which is thermally unstable. On, complexation with DNA, the orientations of R2 and R3 are fixed by tight, binding and their conformations are slightly changed. No significant, changes occur in the chemical shifts of R1 consistent with its loose, interaction with DNA.
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<StructureSection load='1mbg' size='340' side='right'caption='[[1mbg]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mbg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MBG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mbg OCA], [https://pdbe.org/1mbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mbg RCSB], [https://www.ebi.ac.uk/pdbsum/1mbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mbg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mb/1mbg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mbg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved tryptophans in each repeat participate in forming a hydrophobic core. Comparison of the three repeat structures indicated that cavities are found in the hydrophobic core of R2, which is thermally unstable. On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA.
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==About this Structure==
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Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.,Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, et al. Nat Struct Biol. 1995 Apr;2(4):309-20. PMID:7796266<ref>PMID:7796266</ref>
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1MBG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NH2 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MBG OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb., Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, et al., Nat Struct Biol. 1995 Apr;2(4):309-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7796266 7796266]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 1mbg" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Aimoto, S.]]
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[[Category: Ametani, Y.]]
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[[Category: Hirata, Z.]]
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[[Category: Hojo, H.]]
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[[Category: Ishii, S.]]
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[[Category: Morikawa, S.]]
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[[Category: Nakamura, H.]]
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[[Category: Nishimura, Y.]]
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[[Category: Ogata, K.]]
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[[Category: Sarai, A.]]
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[[Category: Yoshimura, S.]]
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[[Category: Zhang, R.]]
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[[Category: NH2]]
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[[Category: protooncogene product]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:18:08 2007''
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Aimoto S]]
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[[Category: Ametani Y]]
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[[Category: Hirata Z]]
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[[Category: Hojo H]]
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[[Category: Ishii S]]
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[[Category: Morikawa S]]
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[[Category: Nakamura H]]
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[[Category: Nishimura Y]]
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[[Category: Ogata K]]
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[[Category: Sarai A]]
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[[Category: Yoshimura S]]
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[[Category: Zhang R]]

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MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2

PDB ID 1mbg

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