1w4l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1w4l", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Current revision (08:53, 6 November 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1w4l.png|left|200px]]
 
-
<!--
+
==Complex of TcAChE with bis-acting galanthamine derivative==
-
The line below this paragraph, containing "STRUCTURE_1w4l", creates the "Structure Box" on the page.
+
<StructureSection load='1w4l' size='340' side='right'caption='[[1w4l]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1w4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W4L FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GL8:GALANTHAMINE+DERIVATIVE'>GL8</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
{{STRUCTURE_1w4l| PDB=1w4l | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4l OCA], [https://pdbe.org/1w4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w4l RCSB], [https://www.ebi.ac.uk/pdbsum/1w4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w4l ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/1w4l_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w4l ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Bifunctional derivatives of the alkaloid galanthamine, designed to interact with both the active site of the enzyme acetylcholinesterase (AChE) and its peripheral cation binding site, have been assayed with Torpedo californica AChE (TcAChE), and the three-dimensional structures of their complexes with the enzyme have been solved by X-ray crystallography. Differences were noted between the IC(50) values obtained for TcAChE and those for Electrophorus electricus AChE. These differences are ascribed to sequence differences in one or two residues lining the active-site gorge of the enzyme. The binding of one of the inhibitors disrupts the native conformation of one wall of the gorge, formed by the loop Trp279-Phe290. It is proposed that flexibility of this loop may permit the binding of inhibitors such as galanthamine, which are too bulky to penetrate the narrow neck of the gorge formed by Tyr121 and Phe330 as seen in the crystal structure.
-
===COMPLEX OF TCACHE WITH BIS-ACTING GALANTHAMINE DERIVATIVE===
+
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.,Greenblatt HM, Guillou C, Guenard D, Argaman A, Botti S, Badet B, Thal C, Silman I, Sussman JL J Am Chem Soc. 2004 Dec 1;126(47):15405-11. PMID:15563167<ref>PMID:15563167</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15563167}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1w4l" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15563167 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_15563167}}
+
-
 
+
-
==About this Structure==
+
-
[[1w4l]] is a 1 chain structure of [[Acetylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W4L OCA].
+
==See Also==
==See Also==
-
*[[AChE bivalent inhibitors (Part II)|AChE bivalent inhibitors (Part II)]]
+
*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
-
*[[Acetylcholinesterase|Acetylcholinesterase]]
+
== References ==
-
*[[Alzheimer's Disease|Alzheimer's Disease]]
+
<references/>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:015563167</ref><ref group="xtra">PMID:009839013</ref><references group="xtra"/>
+
[[Category: Large Structures]]
-
[[Category: Acetylcholinesterase]]
+
[[Category: Tetronarce californica]]
-
[[Category: Torpedo californica]]
+
[[Category: Badet B]]
-
[[Category: Badet, B.]]
+
[[Category: Greenblatt HM]]
-
[[Category: Greenblatt, H M.]]
+
[[Category: Guenard D]]
-
[[Category: Guenard, D.]]
+
[[Category: Guillou C]]
-
[[Category: Guillou, C.]]
+
[[Category: Silman I]]
-
[[Category: Silman, I.]]
+
[[Category: Sussman JL]]
-
[[Category: Sussman, J L.]]
+
[[Category: Thal C]]
-
[[Category: Thal, C.]]
+
-
[[Category: Alzheimer's disease]]
+
-
[[Category: Cholinesterase]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Gpi-anchor]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Muscle]]
+
-
[[Category: Nerve]]
+
-
[[Category: Neurotransmitter degradation]]
+
-
[[Category: Serine esterase]]
+
-
[[Category: Serine hydrolase]]
+
-
[[Category: Synapse]]
+

Current revision

Complex of TcAChE with bis-acting galanthamine derivative

PDB ID 1w4l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1w4l"
Personal tools