1yln

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[[Image:1yln.png|left|200px]]
 
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==The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1==
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The line below this paragraph, containing "STRUCTURE_1yln", creates the "Structure Box" on the page.
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<StructureSection load='1yln' size='340' side='right'caption='[[1yln]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1 Vibrio cholerae O1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YLN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OSE:O-SULFO-L-SERINE'>OSE</scene></td></tr>
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{{STRUCTURE_1yln| PDB=1yln | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yln OCA], [https://pdbe.org/1yln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yln RCSB], [https://www.ebi.ac.uk/pdbsum/1yln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yln ProSAT], [https://www.topsan.org/Proteins/MCSG/1yln TOPSAN]</span></td></tr>
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</table>
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===The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1===
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== Function ==
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[https://www.uniprot.org/uniprot/YCGRL_VIBCH YCGRL_VIBCH] May act as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Increasing levels of c-di-GMP lead to decreased motility (Potential). Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP) with a dissociation constant of 170 nM in the presence of 10 mM KCl and with 100 nM in its absence. Binds 1 to 2 c-di-GMP per subunit. Only 1 c-di-GMP is seen in the wild-type crystal, while 2 are seen in the mutant. Depending on the concentration of K(+) stoichiometries of 1:1, 1.43:1 and 2:1 are determined by isothermal titration calorimetry.
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[1yln]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_o1 Vibrio cholerae o1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YLN OCA].
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Check<jmol>
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<jmolCheckbox>
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==See Also==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yl/1yln_consurf.spt"</scriptWhenChecked>
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*[[C-di-GMP receptors with PilZ domain|C-di-GMP receptors with PilZ domain]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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*[[PilZ domain|PilZ domain]]
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<text>to colour the structure by Evolutionary Conservation</text>
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*[[Protein of Unknown Function VCA0042 from Vibrio cholerae O1|Protein of Unknown Function VCA0042 from Vibrio cholerae O1]]
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</jmolCheckbox>
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[[Category: Vibrio cholerae o1]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yln ConSurf].
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[[Category: Collart, F.]]
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<div style="clear:both"></div>
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[[Category: Joachimiak, A.]]
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__TOC__
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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</StructureSection>
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[[Category: Moy, S.]]
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[[Category: Large Structures]]
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[[Category: Zhang, R.]]
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[[Category: Vibrio cholerae O1]]
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[[Category: Zhou, M.]]
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[[Category: Collart F]]
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[[Category: Beta barrel]]
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[[Category: Joachimiak A]]
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[[Category: Mcsg]]
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[[Category: Moy S]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Zhang R]]
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[[Category: Protein structure initiative]]
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[[Category: Zhou M]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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[[Category: Vibrio cholerae o1]]
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Current revision

The Crystal Structure of the Protein of Unknown Function VCA0042 from Vibrio cholerae O1

PDB ID 1yln

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