2b4y

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[[Image:2b4y.png|left|200px]]
 
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{{STRUCTURE_2b4y| PDB=2b4y | SCENE= }}
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==Crystal Structure of Human Sirtuin homolog 5==
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<StructureSection load='2b4y' size='340' side='right'caption='[[2b4y]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b4y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B4Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b4y OCA], [https://pdbe.org/2b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b4y RCSB], [https://www.ebi.ac.uk/pdbsum/2b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b4y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIR5_HUMAN SIR5_HUMAN] NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.<ref>PMID:18680753</ref> <ref>PMID:21908771</ref> <ref>PMID:24140062</ref> <ref>PMID:22076378</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/2b4y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b4y ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Human Sirtuin homolog 5===
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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{{ABSTRACT_PUBMED_017355872}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2b4y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4Y OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017355872</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Antoshenko, T.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Antoshenko T]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Dong A]]
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[[Category: Loppnau, P.]]
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[[Category: Edwards AM]]
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[[Category: Min, J R.]]
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[[Category: Loppnau P]]
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[[Category: Plotnikov, A N.]]
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[[Category: Min JR]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Plotnikov AN]]
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[[Category: Schuetz, A.]]
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[[Category: Schuetz A]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Histone deacetylase]]
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[[Category: Hydrolase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal Structure of Human Sirtuin homolog 5

PDB ID 2b4y

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