2b4y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:00, 6 November 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2b4y.gif|left|200px]]<br /><applet load="2b4y" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2b4y, resolution 1.90&Aring;" />
 
-
'''Crystal Structure of Human Sirtuin homolog 5'''<br />
 
-
==About this Structure==
+
==Crystal Structure of Human Sirtuin homolog 5==
-
2B4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=APR:'>APR</scene> and <scene name='pdbligand=EPE:'>EPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4Y OCA].
+
<StructureSection load='2b4y' size='340' side='right'caption='[[2b4y]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2b4y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B4Y FirstGlance]. <br>
-
[[Category: Antoshenko, T.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
[[Category: Arrowsmith, C H.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Bochkarev, A.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b4y OCA], [https://pdbe.org/2b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b4y RCSB], [https://www.ebi.ac.uk/pdbsum/2b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b4y ProSAT]</span></td></tr>
-
[[Category: Dong, A.]]
+
</table>
-
[[Category: Edwards, A M.]]
+
== Function ==
-
[[Category: Loppnau, P.]]
+
[https://www.uniprot.org/uniprot/SIR5_HUMAN SIR5_HUMAN] NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.<ref>PMID:18680753</ref> <ref>PMID:21908771</ref> <ref>PMID:24140062</ref> <ref>PMID:22076378</ref>
-
[[Category: Min, J R.]]
+
== Evolutionary Conservation ==
-
[[Category: Plotnikov, A N.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
Check<jmol>
-
[[Category: Schuetz, A.]]
+
<jmolCheckbox>
-
[[Category: Sundstrom, M.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/2b4y_consurf.spt"</scriptWhenChecked>
-
[[Category: Weigelt, J.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
-
[[Category: APR]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: EPE]]
+
</jmolCheckbox>
-
[[Category: ZN]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b4y ConSurf].
-
[[Category: histone deacetylase]]
+
<div style="clear:both"></div>
-
[[Category: sgc]]
+
-
[[Category: structural genomics]]
+
-
[[Category: structural genomics consortium]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:34:12 2008''
+
==See Also==
 +
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Antoshenko T]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Bochkarev A]]
 +
[[Category: Dong A]]
 +
[[Category: Edwards AM]]
 +
[[Category: Loppnau P]]
 +
[[Category: Min JR]]
 +
[[Category: Plotnikov AN]]
 +
[[Category: Schuetz A]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Weigelt J]]

Current revision

Crystal Structure of Human Sirtuin homolog 5

PDB ID 2b4y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b4y"
Personal tools