2c47

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[[Image:2c47.gif|left|200px]]<br /><applet load="2c47" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2c47, resolution 2.40&Aring;" />
 
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'''STRUCTURE OF CASEIN KINASE 1 GAMMA 2'''<br />
 
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==About this Structure==
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==Structure of casein kinase 1 gamma 2==
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2C47 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=5ID:'>5ID</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C47 OCA].
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<StructureSection load='2c47' size='340' side='right'caption='[[2c47]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2c47]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C47 FirstGlance]. <br>
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[[Category: Amos, A.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Arrowsmith, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ID:(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL'>5ID</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Ball, L.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c47 OCA], [https://pdbe.org/2c47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c47 RCSB], [https://www.ebi.ac.uk/pdbsum/2c47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c47 ProSAT]</span></td></tr>
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[[Category: Bullock, A.]]
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</table>
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[[Category: Bunkoczi, G.]]
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== Function ==
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[[Category: Das, S.]]
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[https://www.uniprot.org/uniprot/KC1G2_HUMAN KC1G2_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.<ref>PMID:15342122</ref> <ref>PMID:15077195</ref> <ref>PMID:18794808</ref> <ref>PMID:19005213</ref>
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[[Category: Debreczeni, J.]]
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== Evolutionary Conservation ==
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[[Category: Delft, F Von.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Edwards, A.]]
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Check<jmol>
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[[Category: Eswaran, J.]]
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<jmolCheckbox>
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[[Category: Fedorov, O.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c47_consurf.spt"</scriptWhenChecked>
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[[Category: Knapp, S.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Rellos, P.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Sobott, F.]]
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</jmolCheckbox>
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[[Category: Sundstrom, M.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c47 ConSurf].
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[[Category: Turnbull, A.]]
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<div style="clear:both"></div>
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt, J.]]
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[[Category: 5ID]]
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[[Category: MG]]
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[[Category: actin cytoskeleton organisation]]
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[[Category: atp-binding]]
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[[Category: serine/threonine kinase]]
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[[Category: transferase]]
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[[Category: wnt signaling pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:44:45 2008''
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==See Also==
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Amos A]]
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[[Category: Arrowsmith C]]
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[[Category: Ball L]]
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[[Category: Bullock A]]
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[[Category: Bunkoczi G]]
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[[Category: Das S]]
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[[Category: Debreczeni J]]
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[[Category: Edwards A]]
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[[Category: Eswaran J]]
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[[Category: Fedorov O]]
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[[Category: Knapp S]]
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[[Category: Rellos P]]
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[[Category: Sobott F]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull A]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Structure of casein kinase 1 gamma 2

PDB ID 2c47

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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