2ffk

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{{Seed}}
 
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[[Image:2ffk.png|left|200px]]
 
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==Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure==
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The line below this paragraph, containing "STRUCTURE_2ffk", creates the "Structure Box" on the page.
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<StructureSection load='2ffk' size='340' side='right'caption='[[2ffk]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ffk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffk OCA], [https://pdbe.org/2ffk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffk RCSB], [https://www.ebi.ac.uk/pdbsum/2ffk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffk ProSAT]</span></td></tr>
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{{STRUCTURE_2ffk| PDB=2ffk | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O10647_9POXV O10647_9POXV]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ffk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein 1beta). vCCI binds to the chemokine with 1:1 stoichiometry, forming a complex of 311 aa. vCCI uses residues from its beta-sheet II to interact with a surface of MIP-1beta that includes residues adjacent to its N terminus, as well as residues in the 20's region and the 40's loop. This structure reveals the strategy used by vCCI to tightly bind numerous chemokines while retaining selectivity for the CC chemokine subfamily.
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===Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure===
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Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta.,Zhang L, Derider M, McCornack MA, Jao SC, Isern N, Ness T, Moyer R, LiWang PJ Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13985-90. Epub 2006 Sep 8. PMID:16963564<ref>PMID:16963564</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16963564}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ffk" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16963564 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16963564}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2FFK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rabbitpox_virus Rabbitpox virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFK OCA].
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==Reference==
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<ref group="xtra">PMID:16963564</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Rabbitpox virus]]
[[Category: Rabbitpox virus]]
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[[Category: Zhang, L.]]
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[[Category: Zhang L]]
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[[Category: Chemokine]]
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[[Category: Pox virus]]
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[[Category: Protein-protein complex]]
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[[Category: Viral cc chemokine inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:39:45 2009''
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Current revision

Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure

PDB ID 2ffk

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