2hdl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:10, 6 November 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2hdl.png|left|200px]]
 
-
<!--
+
==Solution structure of Brak/CXCL14==
-
The line below this paragraph, containing "STRUCTURE_2hdl", creates the "Structure Box" on the page.
+
<StructureSection load='2hdl' size='340' side='right'caption='[[2hdl]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2hdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HDL FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdl OCA], [https://pdbe.org/2hdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hdl RCSB], [https://www.ebi.ac.uk/pdbsum/2hdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hdl ProSAT]</span></td></tr>
-
{{STRUCTURE_2hdl| PDB=2hdl | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CXL14_HUMAN CXL14_HUMAN] Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.<ref>PMID:10049774</ref> <ref>PMID:10946286</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/2hdl_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hdl ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The chemokine CXCL14/BRAK participates in immune surveillance by recruiting dendritic cells. CXCL14 gene expression is altered in a number of cancers, but protein expression levels have not been investigated. Here we report that CXCL14 protein can be expressed in primary epithelial cells; however, in several immortalized and cancer cell lines this protein is targeted for polyubiquitylation and proteasomal degradation. We determined the NMR structure of CXCL14 to identify motifs controlling its expression. CXCL14 adopts the canonical chemokine tertiary fold but contains a unique five amino acid insertion (41VSRYR45) relative to other CXC chemokines. Deletion or substitution of key residues within this insertion prevented proteasomal degradation. Furthermore, we defined a 15 amino acid fragment of CXCL14 that is sufficient to induce proteasomal degradation. This study elucidates a post-translational mechanism for the loss of CXCL14 in cancer and a novel mode of chemokine regulation.
-
===Solution structure of Brak/CXCL14===
+
Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome.,Peterson FC, Thorpe JA, Harder AG, Volkman BF, Schwarze SR J Mol Biol. 2006 Nov 3;363(4):813-22. Epub 2006 Aug 26. PMID:16987528<ref>PMID:16987528</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2hdl" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16987528}}, adds the Publication Abstract to the page
+
*[[C-X-C motif chemokine 3D structures|C-X-C motif chemokine 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16987528 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16987528}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2HDL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDL OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16987528</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Harder, A G.]]
+
[[Category: Large Structures]]
-
[[Category: Peterson, F C.]]
+
[[Category: Harder AG]]
-
[[Category: Schwarze, S R.]]
+
[[Category: Peterson FC]]
-
[[Category: Thorpe, J A.]]
+
[[Category: Schwarze SR]]
-
[[Category: Volkman, B F.]]
+
[[Category: Thorpe JA]]
-
[[Category: Brak]]
+
[[Category: Volkman BF]]
-
[[Category: Chemokine]]
+
-
[[Category: Cxcl14]]
+
-
[[Category: Nmr]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:51:13 2009''
+

Current revision

Solution structure of Brak/CXCL14

PDB ID 2hdl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hdl"
Personal tools