3d6x

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[[Image:3d6x.png|left|200px]]
 
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{{STRUCTURE_3d6x| PDB=3d6x | SCENE= }}
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==Crystal structure of Campylobacter jejuni FabZ==
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<StructureSection load='3d6x' size='340' side='right'caption='[[3d6x]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3d6x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_81-176 Campylobacter jejuni subsp. jejuni 81-176]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D6X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6x OCA], [https://pdbe.org/3d6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6x RCSB], [https://www.ebi.ac.uk/pdbsum/3d6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABZ_CAMJJ FABZ_CAMJJ] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.[HAMAP-Rule:MF_00406]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/3d6x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d6x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making FAS II enzymes excellent targets for antibiotics discovery. The beta-hydroxyacyl-ACP dehydratase (FabZ) catalyzes an essential step in the FAS II pathway. Here, we report the structure of Campylobacter jejuni FabZ (CjFabZ), showing a hexamer both in crystals and solution, with each protomer adopting the characteristic hot dog fold. Together with biochemical analysis of CjFabZ, we define the first functional FAS II enzyme from this pathogen, and provide a framework for investigation on roles of FAS II in C. jejuni virulence.
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===Crystal structure of Campylobacter jejuni FabZ===
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Campylobacter jejuni fatty acid synthase II: structural and functional analysis of beta-hydroxyacyl-ACP dehydratase (FabZ).,Kirkpatrick AS, Yokoyama T, Choi KJ, Yeo HJ Biochem Biophys Res Commun. 2009 Mar 6;380(2):407-12. PMID:19280690<ref>PMID:19280690</ref>
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{{ABSTRACT_PUBMED_19280690}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3d6x" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3d6x]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_81-176 Campylobacter jejuni subsp. jejuni 81-176]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6X OCA].
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*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019280690</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Campylobacter jejuni subsp. jejuni 81-176]]
[[Category: Campylobacter jejuni subsp. jejuni 81-176]]
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[[Category: Yeo, H J.]]
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[[Category: Large Structures]]
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[[Category: Yokoyama, T.]]
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[[Category: Yeo HJ]]
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[[Category: Campylobacter jejuni]]
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[[Category: Yokoyama T]]
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[[Category: Dehydratase]]
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[[Category: Fabz]]
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[[Category: Hot dog fold]]
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[[Category: Lipid a biosynthesis]]
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[[Category: Lipid synthesis]]
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[[Category: Lyase]]
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Current revision

Crystal structure of Campylobacter jejuni FabZ

PDB ID 3d6x

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