3d6x

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{{Seed}}
 
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[[Image:3d6x.jpg|left|200px]]
 
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==Crystal structure of Campylobacter jejuni FabZ==
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The line below this paragraph, containing "STRUCTURE_3d6x", creates the "Structure Box" on the page.
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<StructureSection load='3d6x' size='340' side='right'caption='[[3d6x]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3d6x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni_81-176 Campylobacter jejuni subsp. jejuni 81-176]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D6X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3d6x| PDB=3d6x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6x OCA], [https://pdbe.org/3d6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6x RCSB], [https://www.ebi.ac.uk/pdbsum/3d6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABZ_CAMJJ FABZ_CAMJJ] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.[HAMAP-Rule:MF_00406]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/3d6x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d6x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making FAS II enzymes excellent targets for antibiotics discovery. The beta-hydroxyacyl-ACP dehydratase (FabZ) catalyzes an essential step in the FAS II pathway. Here, we report the structure of Campylobacter jejuni FabZ (CjFabZ), showing a hexamer both in crystals and solution, with each protomer adopting the characteristic hot dog fold. Together with biochemical analysis of CjFabZ, we define the first functional FAS II enzyme from this pathogen, and provide a framework for investigation on roles of FAS II in C. jejuni virulence.
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===Crystal structure of Campylobacter jejuni FabZ===
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Campylobacter jejuni fatty acid synthase II: structural and functional analysis of beta-hydroxyacyl-ACP dehydratase (FabZ).,Kirkpatrick AS, Yokoyama T, Choi KJ, Yeo HJ Biochem Biophys Res Commun. 2009 Mar 6;380(2):407-12. PMID:19280690<ref>PMID:19280690</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3d6x" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19280690}}, adds the Publication Abstract to the page
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*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19280690 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19280690}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Campylobacter jejuni subsp. jejuni 81-176]]
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3D6X is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6X OCA].
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[[Category: Large Structures]]
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[[Category: Yeo HJ]]
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==Reference==
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[[Category: Yokoyama T]]
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<ref group="xtra">PMID:19280690</ref><references group="xtra"/>
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[[Category: Bacteria]]
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[[Category: Yeo, H J.]]
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[[Category: Yokoyama, T.]]
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[[Category: Campylobacter jejuni]]
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[[Category: Cytoplasm]]
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[[Category: Dehydratase]]
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[[Category: Fabz]]
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[[Category: Hot dog fold]]
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[[Category: Lipid a biosynthesis]]
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[[Category: Lipid synthesis]]
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[[Category: Lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 09:59:13 2009''
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Current revision

Crystal structure of Campylobacter jejuni FabZ

PDB ID 3d6x

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