3gci

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[[Image:3gci.png|left|200px]]
 
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{{STRUCTURE_3gci| PDB=3gci | SCENE= }}
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==Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution==
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<StructureSection load='3gci' size='340' side='right'caption='[[3gci]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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===Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GCI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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[[3gci]] is a 2 chain structure of [[Amyloid precursor protein]] and [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCI OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gci OCA], [https://pdbe.org/3gci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gci RCSB], [https://www.ebi.ac.uk/pdbsum/3gci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gci ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2A3_NAJSG PA2A3_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/3gci_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gci ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Amyloid precursor protein|Amyloid precursor protein]]
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*[[Amyloid precursor protein 3D structures|Amyloid precursor protein 3D structures]]
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
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[[Category: Bhushan, A.]]
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[[Category: Bhushan A]]
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[[Category: Kaur, P.]]
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[[Category: Kaur P]]
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[[Category: Mirza, Z.]]
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[[Category: Mirza Z]]
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[[Category: Sharma, S.]]
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[[Category: Sharma S]]
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[[Category: Singh, N.]]
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[[Category: Singh N]]
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[[Category: Singh, T P.]]
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[[Category: Singh TP]]
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[[Category: Sinha, M.]]
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[[Category: Sinha M]]
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[[Category: Srinivasan, A.]]
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[[Category: Srinivasan A]]
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[[Category: Vikram, G.]]
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[[Category: Vikram G]]
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[[Category: Amyloid beta]]
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[[Category: Heptapeptide]]
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[[Category: Hydrolase]]
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[[Category: Lipid degradation]]
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[[Category: Metal-binding]]
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[[Category: Phospholipase a2]]
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[[Category: Secreted]]
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Current revision

Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution

PDB ID 3gci

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