3l7z

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{{Seed}}
 
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[[Image:3l7z.jpg|left|200px]]
 
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==Crystal structure of the S. solfataricus archaeal exosome==
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The line below this paragraph, containing "STRUCTURE_3l7z", creates the "Structure Box" on the page.
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<StructureSection load='3l7z' size='340' side='right'caption='[[3l7z]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l7z]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L7Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3l7z| PDB=3l7z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7z OCA], [https://pdbe.org/3l7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l7z RCSB], [https://www.ebi.ac.uk/pdbsum/3l7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l7z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RRP42_SACS2 RRP42_SACS2] Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.[HAMAP-Rule:MF_00622]<ref>PMID:15951817</ref> <ref>PMID:20488184</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l7/3l7z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l7z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BACKGROUND: The exosome complex is an essential RNA 3'-end processing and degradation machinery. In archaeal organisms, the exosome consists of a catalytic ring and an RNA-binding ring, both of which were previously reported to assume three-fold symmetry. METHODOLOGY/PRINCIPAL FINDINGS: Here we report an asymmetric 2.9 A Sulfolobus solfataricus archaeal exosome structure in which the three-fold symmetry is broken due to combined rigid body and thermal motions mainly within the RNA-binding ring. Since increased conformational flexibility was also observed in the RNA-binding ring of the related bacterial PNPase, we speculate that this may reflect an evolutionarily conserved mechanism to accommodate diverse RNA substrates for degradation. CONCLUSION/SIGNIFICANCE: This study clearly shows the dynamic structures within the RNA-binding domains, which provides additional insights on mechanism of asymmetric RNA binding and processing.
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===Crystal structure of the S. solfataricus archaeal exosome===
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Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring.,Lu C, Ding F, Ke A PLoS One. 2010 Jan 15;5(1):e8739. PMID:20090900<ref>PMID:20090900</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20090900}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3l7z" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20090900 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20090900}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3L7Z is a 9 chains structure with sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7Z OCA].
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[[Category: Saccharolobus solfataricus]]
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[[Category: Ding F]]
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==Reference==
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[[Category: Ke A]]
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<ref group="xtra">PMID:20090900</ref><references group="xtra"/>
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[[Category: Lu C]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Ding, F.]]
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[[Category: Ke, A.]]
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[[Category: Lu, C.]]
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[[Category: Asymmetry]]
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[[Category: Conformation flexibility]]
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[[Category: Exosome]]
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[[Category: Hydrolase-rna binding protein complex]]
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[[Category: Rna degradation]]
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[[Category: Rna processing]]
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[[Category: Thermal motion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:49:59 2010''
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Current revision

Crystal structure of the S. solfataricus archaeal exosome

PDB ID 3l7z

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