3riu

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[[Image:3riu.jpg|left|200px]]
 
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==Crystal structure of Drosophila hexameric C3PO formed by truncated Translin and Trax==
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The line below this paragraph, containing "STRUCTURE_3riu", creates the "Structure Box" on the page.
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<StructureSection load='3riu' size='340' side='right'caption='[[3riu]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3riu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RIU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3riu| PDB=3riu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3riu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3riu OCA], [https://pdbe.org/3riu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3riu RCSB], [https://www.ebi.ac.uk/pdbsum/3riu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3riu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7JVK6_DROME Q7JVK6_DROME]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Trax-translin heteromers, also known as C3PO, have been proposed to activate the RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. We report on the crystal structure of hexameric Drosophila C3PO formed by truncated translin and Trax, along with electron microscopic and mass spectrometric studies on octameric C3PO formed by full-length translin and Trax. Our studies establish that Trax adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly. The catalytic pockets of Trax subunits are located within the interior chamber of the octameric scaffold. Truncated C3PO, like full-length C3PO, shows endoRNase activity that leaves 3'-hydroxyl-cleaved ends. We have measured the catalytic activity of C3PO and shown it to cleave almost stoichiometric amounts of substrate per second.
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===Crystal structure of Drosophila hexameric C3PO formed by truncated Translin and Trax===
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Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.,Tian Y, Simanshu DK, Ascano M, Diaz-Avalos R, Park AY, Juranek SA, Rice WJ, Yin Q, Robinson CV, Tuschl T, Patel DJ Nat Struct Mol Biol. 2011 Jun;18(6):658-64. Epub 2011 May 8. PMID:21552261<ref>PMID:21552261</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3riu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIU OCA].
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<div class="pdbe-citations 3riu" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Patel, D J.]]
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[[Category: Large Structures]]
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[[Category: Simanshu, D K.]]
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[[Category: Patel DJ]]
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[[Category: Tian, Y.]]
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[[Category: Simanshu DK]]
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[[Category: Tian Y]]

Current revision

Crystal structure of Drosophila hexameric C3PO formed by truncated Translin and Trax

PDB ID 3riu

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