5fxu

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(New page: '''Unreleased structure''' The entry 5fxu is ON HOLD Authors: Li, S., Rissanen, I., Zeltina, A., Hepojoki, J., Raghwani, J., Harlos, K., Pybus, O.G., Huiskonen, J.T., Bowden, T.A. Desc...)
Current revision (11:46, 6 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5fxu is ON HOLD
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==Crystal Structure of Puumala virus Gn glycoprotein ectodomain==
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<StructureSection load='5fxu' size='340' side='right'caption='[[5fxu]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fxu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthohantavirus_puumalaense Orthohantavirus puumalaense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FXU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fxu OCA], [https://pdbe.org/5fxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fxu RCSB], [https://www.ebi.ac.uk/pdbsum/5fxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fxu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WJ31_9VIRU Q9WJ31_9VIRU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of intact Gn-Gc spike complexes from the closely related but non-pathogenic Tula hantavirus localized Gn tetramers to the membrane-distal surface of the virion. The accuracy of the fitting was corroborated by epitope mapping and genetic analysis of available PUUV sequences. Interestingly, Gn exhibits greater non-synonymous sequence diversity than the less accessible Gc, supporting a role of the host humoral immune response in exerting selective pressure on the virus surface. The fold of PUUV Gn is likely to be widely conserved across hantaviruses.
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Authors: Li, S., Rissanen, I., Zeltina, A., Hepojoki, J., Raghwani, J., Harlos, K., Pybus, O.G., Huiskonen, J.T., Bowden, T.A.
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A Molecular-Level Account of the Antigenic Hantaviral Surface.,Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA Cell Rep. 2016 May 3;15(5):959-67. doi: 10.1016/j.celrep.2016.03.082. Epub 2016, Apr 21. PMID:27117403<ref>PMID:27117403</ref>
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Description: Crystal Structure of Puumala virus Gn glycoprotein ectodomain
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Li, S]]
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<div class="pdbe-citations 5fxu" style="background-color:#fffaf0;"></div>
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[[Category: Raghwani, J]]
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== References ==
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[[Category: Pybus, O.G]]
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<references/>
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[[Category: Zeltina, A]]
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__TOC__
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[[Category: Rissanen, I]]
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</StructureSection>
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[[Category: Bowden, T.A]]
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[[Category: Large Structures]]
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[[Category: Huiskonen, J.T]]
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[[Category: Orthohantavirus puumalaense]]
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[[Category: Harlos, K]]
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[[Category: Bowden TA]]
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[[Category: Hepojoki, J]]
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[[Category: Harlos K]]
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[[Category: Hepojoki J]]
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[[Category: Huiskonen JT]]
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[[Category: Li S]]
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[[Category: Pybus OG]]
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[[Category: Raghwani J]]
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[[Category: Rissanen I]]
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[[Category: Zeltina A]]

Current revision

Crystal Structure of Puumala virus Gn glycoprotein ectodomain

PDB ID 5fxu

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