5tcd

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==Human alkaline sphingomyelinase (ENPP7) in complex with phosphocholine==
==Human alkaline sphingomyelinase (ENPP7) in complex with phosphocholine==
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<StructureSection load='5tcd' size='340' side='right' caption='[[5tcd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='5tcd' size='340' side='right'caption='[[5tcd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tcd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TCD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TCD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphingomyelin_phosphodiesterase Sphingomyelin phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.12 3.1.4.12] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tcd OCA], [http://pdbe.org/5tcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tcd RCSB], [http://www.ebi.ac.uk/pdbsum/5tcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tcd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tcd OCA], [https://pdbe.org/5tcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tcd RCSB], [https://www.ebi.ac.uk/pdbsum/5tcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tcd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ENPP7_HUMAN ENPP7_HUMAN]] Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.<ref>PMID:12885774</ref>
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[https://www.uniprot.org/uniprot/ENPP7_HUMAN ENPP7_HUMAN] Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.<ref>PMID:12885774</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5tcd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5tcd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures|Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]]
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*[[Sphingomyelinase|Sphingomyelinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sphingomyelin phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Gorelik, A]]
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[[Category: Large Structures]]
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[[Category: Illes, K]]
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[[Category: Gorelik A]]
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[[Category: Liu, F]]
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[[Category: Illes K]]
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[[Category: Nagar, B]]
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[[Category: Liu F]]
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[[Category: Glycosylphosphatidylinositol]]
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[[Category: Nagar B]]
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[[Category: Hydrolase]]
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[[Category: Phosphocholine]]
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[[Category: Sphingomyelin]]
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[[Category: Sphingomyelinase]]
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Current revision

Human alkaline sphingomyelinase (ENPP7) in complex with phosphocholine

PDB ID 5tcd

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