5w4v

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==Structure of RORgt bound to a tertiary alcohol==
==Structure of RORgt bound to a tertiary alcohol==
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<StructureSection load='5w4v' size='340' side='right' caption='[[5w4v]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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<StructureSection load='5w4v' size='340' side='right'caption='[[5w4v]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w4v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W4V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w4v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W4V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9WA:(R)-(4-chloro-2-methoxy-3-{[4-(1H-pyrazol-1-yl)phenyl]methyl}quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol'>9WA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w4r|5w4r]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9WA:(~{R})-[4-chloranyl-2-methoxy-3-[(4-pyrazol-1-ylphenyl)methyl]quinolin-6-yl]-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanol'>9WA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w4v OCA], [http://pdbe.org/5w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w4v RCSB], [http://www.ebi.ac.uk/pdbsum/5w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w4v ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w4v OCA], [https://pdbe.org/5w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w4v RCSB], [https://www.ebi.ac.uk/pdbsum/5w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w4v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hars, U]]
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[[Category: Homo sapiens]]
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[[Category: Spurlino, J]]
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[[Category: Large Structures]]
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[[Category: Nuclear protein]]
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[[Category: Hars U]]
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[[Category: Rorgt nuclear hormone receptor]]
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[[Category: Spurlino J]]

Current revision

Structure of RORgt bound to a tertiary alcohol

PDB ID 5w4v

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