6u5z

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m (Protected "6u5z" [edit=sysop:move=sysop])
Current revision (13:10, 6 November 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6u5z is ON HOLD until Paper Publication
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==Cryo-EM structure of E. coli LonA S679A==
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<SX load='6u5z' size='340' side='right' viewer='molstar' caption='[[6u5z]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6u5z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U5Z FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5z OCA], [https://pdbe.org/6u5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u5z RCSB], [https://www.ebi.ac.uk/pdbsum/6u5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LON_ECOLI LON_ECOLI] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.<ref>PMID:12135363</ref> <ref>PMID:16584195</ref> <ref>PMID:19721064</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Botos I]]
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[[Category: Lountos GT]]
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[[Category: Weimin W]]
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[[Category: Wlodawer A]]

Current revision

Cryo-EM structure of E. coli LonA S679A

6u5z, resolution 3.50Å

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OCA

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