7ezh

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'''Unreleased structure'''
 
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The entry 7ezh is ON HOLD until Paper Publication
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==Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex==
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<StructureSection load='7ezh' size='340' side='right'caption='[[7ezh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7ezh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EZH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ezh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ezh OCA], [https://pdbe.org/7ezh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ezh RCSB], [https://www.ebi.ac.uk/pdbsum/7ezh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ezh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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Authors: Liu, Q.F., Yang, D.H., Zhuang, Y.W., Croll, T.I., Cai, X.Q., Duan, J., Dai, A.T., Yin, W.C., Ye, C.Y., Zhou, F.L., Wu, B.L., Zhao, Q., Xu, H.E., Wang, M.W., Jiang, Y.
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==See Also==
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*[[Transducin 3D structures|Transducin 3D structures]]
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Description: Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Xu, H.E]]
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__TOC__
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[[Category: Dai, A.T]]
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</StructureSection>
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[[Category: Duan, J]]
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[[Category: Homo sapiens]]
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[[Category: Zhuang, Y.W]]
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[[Category: Large Structures]]
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[[Category: Liu, Q.F]]
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[[Category: Synthetic construct]]
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[[Category: Wu, B.L]]
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[[Category: Cai XQ]]
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[[Category: Yin, W.C]]
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[[Category: Croll TI]]
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[[Category: Ye, C.Y]]
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[[Category: Dai AT]]
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[[Category: Wang, M.W]]
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[[Category: Duan J]]
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[[Category: Cai, X.Q]]
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[[Category: Jiang Y]]
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[[Category: Yang, D.H]]
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[[Category: Liu QF]]
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[[Category: Jiang, Y]]
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[[Category: Wang MW]]
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[[Category: Zhou, F.L]]
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[[Category: Wu BL]]
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[[Category: Zhao, Q]]
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[[Category: Xu HE]]
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[[Category: Croll, T.I]]
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[[Category: Yang DH]]
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[[Category: Ye CY]]
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[[Category: Yin WC]]
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[[Category: Zhao Q]]
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[[Category: Zhou FL]]
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[[Category: Zhuang YW]]

Current revision

Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex

PDB ID 7ezh

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