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1ua7

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[[Image:1ua7.gif|left|200px]]
[[Image:1ua7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ua7 |SIZE=350|CAPTION= <scene name='initialview01'>1ua7</scene>, resolution 2.21&Aring;
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The line below this paragraph, containing "STRUCTURE_1ua7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=GLD:4,6-DIDEOXYGLUCOSE'>GLD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ua7| PDB=1ua7 | SCENE= }}
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|RELATEDENTRY=[[1bag|1BAG]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ua7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ua7 OCA], [http://www.ebi.ac.uk/pdbsum/1ua7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ua7 RCSB]</span>
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}}
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'''Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose'''
'''Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose'''
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[[Category: Momma, M.]]
[[Category: Momma, M.]]
[[Category: Takase, K.]]
[[Category: Takase, K.]]
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[[Category: acarbose]]
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[[Category: Acarbose]]
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[[Category: beta-alpha-barrel]]
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[[Category: Beta-alpha-barrel]]
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[[Category: greek-key motif]]
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[[Category: Greek-key motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:57:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:28 2008''
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Revision as of 07:57, 3 May 2008

Image:1ua7.gif

Template:STRUCTURE 1ua7

Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose


Overview

The crystal structure of Bacillus subtilis alpha-amylase, in complex with the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide in the active site as a result of transglycosylation. After comparison with the known structure of the catalytic-site mutant complexed with the native substrate maltopentaose, it is suggested that the present structure represents a mimic intermediate in the initial stage of the catalytic process.

About this Structure

1UA7 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose., Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H, J Bacteriol. 2003 Dec;185(23):6981-4. PMID:14617662 Page seeded by OCA on Sat May 3 10:57:36 2008

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