1bqu

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(New page: 200px<br /> <applet load="1bqu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bqu, resolution 2.00&Aring;" /> '''CYTOKYNE-BINDING RE...)
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[[Image:1bqu.gif|left|200px]]<br />
 
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<applet load="1bqu" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bqu, resolution 2.00&Aring;" />
 
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'''CYTOKYNE-BINDING REGION OF GP130'''<br />
 
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==Overview==
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==CYTOKYNE-BINDING REGION OF GP130==
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The structure of the cytokine-binding homology region of the cell surface, receptor gp130 has been determined by X-ray crystallography at 2.0 A, resolution. The beta sandwich structure of the two domains conforms to the, topology of the cytokine receptor superfamily. This first structure of an, uncomplexed receptor exhibits a similar L-shaped quaternary structure to, that of ligand-bound family members and suggests a limited flexibility in, relative domain orientation of some 3 degrees. The putative ligand-binding, loops are relatively rigid, with a phenylalanine side chain similarly, positioned to exposed aromatic residues implicated in ligand binding for, other such receptors. The positioning and structure of the N-terminal, portion of the polypeptide chain have implications for the structure and, function of cytokine receptors, such as gp130, which contain an additional, N-terminal immunoglobulin-like domain.
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<StructureSection load='1bqu' size='340' side='right'caption='[[1bqu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BQU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqu OCA], [https://pdbe.org/1bqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bqu RCSB], [https://www.ebi.ac.uk/pdbsum/1bqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bqu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL6RB_HUMAN IL6RB_HUMAN] Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/1bqu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bqu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.
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==About this Structure==
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Crystal structure of a cytokine-binding region of gp130.,Bravo J, Staunton D, Heath JK, Jones EY EMBO J. 1998 Mar 16;17(6):1665-74. PMID:9501088<ref>PMID:9501088</ref>
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1BQU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BQU OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of a cytokine-binding region of gp130., Bravo J, Staunton D, Heath JK, Jones EY, EMBO J. 1998 Mar 16;17(6):1665-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9501088 9501088]
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</div>
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<div class="pdbe-citations 1bqu" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bravo, J.]]
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[[Category: Bravo J]]
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[[Category: Heath, J.K.]]
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[[Category: Heath JK]]
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[[Category: Jones, E.Y.]]
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[[Category: Jones EY]]
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[[Category: Staunton, D.]]
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[[Category: Staunton D]]
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[[Category: GOL]]
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[[Category: SO4]]
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[[Category: cytokine receptor]]
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[[Category: glycoprotein 130]]
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[[Category: gp130]]
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[[Category: interleukine 6 receptor beta subunit]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:13:44 2007''
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Current revision

CYTOKYNE-BINDING REGION OF GP130

PDB ID 1bqu

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