1bwz

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[[Image:1bwz.png|left|200px]]
 
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{{STRUCTURE_1bwz| PDB=1bwz | SCENE= }}
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==DIAMINOPIMELATE EPIMERASE FROM HEMOPHILUS INFLUENZAE==
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<StructureSection load='1bwz' size='340' side='right'caption='[[1bwz]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BWZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bwz OCA], [https://pdbe.org/1bwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bwz RCSB], [https://www.ebi.ac.uk/pdbsum/1bwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bwz ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/1bwz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bwz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Haemophilus influenzae diaminopimelate epimerase was cloned, expressed, purified, and crystallized in the C2221 space group (a = 102.1 A, b = 115.4 A, c = 66.3 A, alpha = beta = gamma = 90 degrees). The three-dimensional structure was solved to 2.7 A using a single Pt derivative and the Se-Met-substituted enzyme to a conventional R factor of 19.0% (Rfree = 24.2%). The 274 amino acid enzyme consists of two structurally homologous domains, each containing eight beta-strands and two alpha-helices. Diaminopimelate epimerase is a representative of the PLP-independent amino acid racemases, for which no structure has yet been determined and substantial evidence exists supporting the role of two cysteine residues as the catalytic acid and base. Cys73 of the amino terminal domain is found in disulfide linkage, at the domain interface, with Cys217 of the carboxy terminal domain, and we suggest that these two cysteine residues in the reduced, active enzyme function as the acid and base in the mechanism.
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===DIAMINOPIMELATE EPIMERASE FROM HEMOPHILUS INFLUENZAE===
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Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.,Cirilli M, Zheng R, Scapin G, Blanchard JS Biochemistry. 1998 Nov 24;37(47):16452-8. PMID:9843410<ref>PMID:9843410</ref>
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{{ABSTRACT_PUBMED_9843410}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1bwz" style="background-color:#fffaf0;"></div>
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[[1bwz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWZ OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009843410</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Diaminopimelate epimerase]]
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Blanchard, J S.]]
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[[Category: Large Structures]]
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[[Category: Cirilli, M.]]
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[[Category: Blanchard JS]]
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[[Category: Scapin, G.]]
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[[Category: Cirilli M]]
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[[Category: Zheng, R.]]
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[[Category: Scapin G]]
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[[Category: Isomerase]]
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[[Category: Zheng R]]
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[[Category: Metabolic role]]
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[[Category: Structural classification]]
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Current revision

DIAMINOPIMELATE EPIMERASE FROM HEMOPHILUS INFLUENZAE

PDB ID 1bwz

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