1bwz

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{{Seed}}
 
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[[Image:1bwz.png|left|200px]]
 
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==DIAMINOPIMELATE EPIMERASE FROM HEMOPHILUS INFLUENZAE==
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The line below this paragraph, containing "STRUCTURE_1bwz", creates the "Structure Box" on the page.
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<StructureSection load='1bwz' size='340' side='right'caption='[[1bwz]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BWZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bwz OCA], [https://pdbe.org/1bwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bwz RCSB], [https://www.ebi.ac.uk/pdbsum/1bwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bwz ProSAT]</span></td></tr>
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{{STRUCTURE_1bwz| PDB=1bwz | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/1bwz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bwz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Haemophilus influenzae diaminopimelate epimerase was cloned, expressed, purified, and crystallized in the C2221 space group (a = 102.1 A, b = 115.4 A, c = 66.3 A, alpha = beta = gamma = 90 degrees). The three-dimensional structure was solved to 2.7 A using a single Pt derivative and the Se-Met-substituted enzyme to a conventional R factor of 19.0% (Rfree = 24.2%). The 274 amino acid enzyme consists of two structurally homologous domains, each containing eight beta-strands and two alpha-helices. Diaminopimelate epimerase is a representative of the PLP-independent amino acid racemases, for which no structure has yet been determined and substantial evidence exists supporting the role of two cysteine residues as the catalytic acid and base. Cys73 of the amino terminal domain is found in disulfide linkage, at the domain interface, with Cys217 of the carboxy terminal domain, and we suggest that these two cysteine residues in the reduced, active enzyme function as the acid and base in the mechanism.
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===DIAMINOPIMELATE EPIMERASE FROM HEMOPHILUS INFLUENZAE===
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Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.,Cirilli M, Zheng R, Scapin G, Blanchard JS Biochemistry. 1998 Nov 24;37(47):16452-8. PMID:9843410<ref>PMID:9843410</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9843410}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1bwz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9843410 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9843410}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1BWZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWZ OCA].
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==Reference==
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Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase., Cirilli M, Zheng R, Scapin G, Blanchard JS, Biochemistry. 1998 Nov 24;37(47):16452-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9843410 9843410]
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[[Category: Diaminopimelate epimerase]]
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blanchard, J S.]]
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[[Category: Blanchard JS]]
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[[Category: Cirilli, M.]]
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[[Category: Cirilli M]]
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[[Category: Scapin, G.]]
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[[Category: Scapin G]]
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[[Category: Zheng, R.]]
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[[Category: Zheng R]]
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[[Category: Metabolic role]]
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[[Category: Structural classification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:51:08 2008''
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Current revision

DIAMINOPIMELATE EPIMERASE FROM HEMOPHILUS INFLUENZAE

PDB ID 1bwz

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