1by2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1by2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1by2, resolution 2.00&Aring;" /> '''STRUCTURE OF M2BP S...)
Current revision (23:50, 20 November 2024) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1by2.gif|left|200px]]<br />
 
-
<applet load="1by2" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1by2, resolution 2.00&Aring;" />
 
-
'''STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN'''<br />
 
-
==Overview==
+
==STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN==
-
Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell, surface molecules and in some secreted proteins, where they are thought to, mediate ligand binding. We have determined the crystal structure at 2.0 A, resolution of the SRCR domain of Mac-2 binding protein (M2BP), a, tumor-associated antigen and matrix protein. The structure reveals a, curved six-stranded beta-sheet cradling an alpha-helix. Structure-based, sequence alignment demonstrates that the M2BP SRCR domain is a valid, template for the entire SRCR protein superfamily. This allows an, interpretation of previous mutagenesis data on ligand binding to the, lymphocyte receptor CD6.
+
<StructureSection load='1by2' size='340' side='right'caption='[[1by2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1by2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BY2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1by2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by2 OCA], [https://pdbe.org/1by2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1by2 RCSB], [https://www.ebi.ac.uk/pdbsum/1by2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1by2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LG3BP_HUMAN LG3BP_HUMAN] Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.<ref>PMID:8034587</ref> <ref>PMID:11146440</ref> <ref>PMID:9501082</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/1by2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1by2 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell surface molecules and in some secreted proteins, where they are thought to mediate ligand binding. We have determined the crystal structure at 2.0 A resolution of the SRCR domain of Mac-2 binding protein (M2BP), a tumor-associated antigen and matrix protein. The structure reveals a curved six-stranded beta-sheet cradling an alpha-helix. Structure-based sequence alignment demonstrates that the M2BP SRCR domain is a valid template for the entire SRCR protein superfamily. This allows an interpretation of previous mutagenesis data on ligand binding to the lymphocyte receptor CD6.
-
==About this Structure==
+
Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily.,Hohenester E, Sasaki T, Timpl R Nat Struct Biol. 1999 Mar;6(3):228-32. PMID:10074941<ref>PMID:10074941</ref>
-
1BY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BY2 OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily., Hohenester E, Sasaki T, Timpl R, Nat Struct Biol. 1999 Mar;6(3):228-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10074941 10074941]
+
</div>
 +
<div class="pdbe-citations 1by2" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hohenester, E.]]
+
[[Category: Hohenester E]]
-
[[Category: Sasaki, T.]]
+
[[Category: Sasaki T]]
-
[[Category: Timpl, R.]]
+
[[Category: Timpl R]]
-
[[Category: NAG]]
+
-
[[Category: extracellular matrix]]
+
-
[[Category: extracellular module]]
+
-
[[Category: glycosylated protein]]
+
-
[[Category: scavenger receptor]]
+
-
[[Category: tumour-associated antigen]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:15:20 2007''
+

Current revision

STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN

PDB ID 1by2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1by2"
Personal tools