1eyr

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{{Seed}}
 
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[[Image:1eyr.png|left|200px]]
 
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==Structure of a sialic acid activating synthetase, CMP acylneuraminate synthetase in the presence and absence of CDP==
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The line below this paragraph, containing "STRUCTURE_1eyr", creates the "Structure Box" on the page.
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<StructureSection load='1eyr' size='340' side='right'caption='[[1eyr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1eyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EYR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1eyr| PDB=1eyr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eyr OCA], [https://pdbe.org/1eyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eyr RCSB], [https://www.ebi.ac.uk/pdbsum/1eyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eyr ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1eyr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eyr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The x-ray crystallographic structure of selenomethionyl cytosine-5'-monophosphate-acylneuraminate synthetase (CMP-NeuAc synthetase) from Neisseria meningitidis has been determined at 2.0-A resolution using multiple-wavelength anomalous dispersion phasing, and a second structure, in the presence of the substrate analogue CDP, has been determined at 2.2-A resolution by molecular replacement. This work identifies the active site residues for this class of enzyme for the first time. The detailed interactions between the enzyme and CDP within the mononucleotide-binding pocket are directly observed, and the acylneuraminate-binding pocket has also been identified. A model of acylneuraminate bound to CMP-NeuAc synthetase has been constructed and provides a structural basis for understanding the mechanism of production of "activated" sialic acids. Sialic acids are key saccharide components on the surface of mammalian cells and can be virulence factors in a variety of bacterial species (e.g. Neisseria, Haemophilus, group B streptococci, etc.). As such, the identification of the bacterial CMP-NeuAc synthetase active site can serve as a starting point for rational drug design strategies.
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===Structure of a sialic acid activating synthetase, CMP acylneuraminate synthetase in the presence and absence of CDP===
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Structure of a sialic acid-activating synthetase, CMP-acylneuraminate synthetase in the presence and absence of CDP.,Mosimann SC, Gilbert M, Dombroswki D, To R, Wakarchuk W, Strynadka NC J Biol Chem. 2001 Mar 16;276(11):8190-6. Epub 2000 Dec 11. PMID:11113120<ref>PMID:11113120</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11113120}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1eyr" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11113120 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11113120}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1EYR is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYR OCA].
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==Reference==
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<ref group="xtra">PMID:11113120</ref><references group="xtra"/>
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[[Category: N-acylneuraminate cytidylyltransferase]]
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[[Category: Neisseria meningitidis]]
[[Category: Neisseria meningitidis]]
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[[Category: Dombrowski, D.]]
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[[Category: Dombrowski D]]
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[[Category: Gilbert, M.]]
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[[Category: Gilbert M]]
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[[Category: Mosimann, S C.]]
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[[Category: Mosimann SC]]
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[[Category: Strynadka, N C.]]
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[[Category: Strynadka NC]]
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[[Category: Wakarchuk, W.]]
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[[Category: Wakarchuk W]]
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[[Category: Acylneuraminate]]
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[[Category: Cdp]]
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[[Category: Sialic acid]]
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[[Category: Synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:07:14 2009''
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Current revision

Structure of a sialic acid activating synthetase, CMP acylneuraminate synthetase in the presence and absence of CDP

PDB ID 1eyr

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