1f11

From Proteopedia

(Difference between revisions)

Current revision

F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY

Structural highlights

1f11 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KV3AD_MOUSE IGKC_MOUSE

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of the Fab fragment from the monoclonal anti-preS2 antibody F124 (IgG1,kappa) has been solved by molecular replacement and refined at 3.0 A resolution. The Fab crystallizes with two independent molecules in the asymmetric unit. F124 recognizes an epitope contained within the preS2 segment between residues 120 and 132 of the surface antigen of hepatitis B virus. The antibody shows a high affinity for the glycan N-linked to Asn123, but it also cross-reacts with the non-glycosylated peptide fragment 120-132. Although crystallization was performed in the presence of an eightfold excess of the cross-reactive peptide, no evidence for the ligand was found in the antigen-binding site, which is close to a neighbouring molecule in the crystal lattice. The antigen-binding site has a groove-like topology which is modulated with pocket-like cavities. It is characterized by a large number of tyrosine and aspartate residues. The importance of germ-line mutations at the binding site is discussed.

Structure of the Fab fragment from F124, a monoclonal antibody specific for hepatitis B surface antigen.,Saul FA, Vulliez-Le Normand B, Passafiume M, Riottot MM, Bentley GA Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):945-51. PMID:10944330^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Saul FA, Vulliez-Le Normand B, Passafiume M, Riottot MM, Bentley GA. Structure of the Fab fragment from F124, a monoclonal antibody specific for hepatitis B surface antigen. Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):945-51. PMID:10944330

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f11"

@@ Line 3: / Line 3: @@
 <StructureSection load='1f11' size='340' side='right'caption='[[1f11]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1f11]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1F11 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1f11]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F11 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f11 OCA], [http://pdbe.org/1f11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1f11 RCSB], [http://www.ebi.ac.uk/pdbsum/1f11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1f11 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f11 OCA], [https://pdbe.org/1f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f11 RCSB], [https://www.ebi.ac.uk/pdbsum/1f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f11 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/KV3AD_MOUSE KV3AD_MOUSE] [https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 11: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/1f11_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 31: / Line 34: @@
 [[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Bentley, G A]]
+[[Category: Bentley GA]]
-[[Category: Normand, B Vulliez-Le]]
+[[Category: Passafiume M]]
-[[Category: Passafiume, M]]
+[[Category: Riottot MM]]
-[[Category: Riottot, M M]]
+[[Category: Saul FA]]
-[[Category: Saul, F A]]
+[[Category: Vulliez-Le Normand B]]
-[[Category: Antibody]]
-[[Category: Fab]]
-[[Category: Hepatitis b]]
-[[Category: Immune system]]
-[[Category: Immunoglobulin]]
-[[Category: Pres2]]

1f11

From Proteopedia

Current revision

F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox