1ha6

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{{Seed}}
 
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[[Image:1ha6.png|left|200px]]
 
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==NMR Solution Structure of Murine CCL20/MIP-3a Chemokine==
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The line below this paragraph, containing "STRUCTURE_1ha6", creates the "Structure Box" on the page.
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<StructureSection load='1ha6' size='340' side='right'caption='[[1ha6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ha6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HA6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ha6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ha6 OCA], [https://pdbe.org/1ha6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ha6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ha6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ha6 ProSAT]</span></td></tr>
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{{STRUCTURE_1ha6| PDB=1ha6 | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/1ha6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ha6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CCL20/MIP-3alpha is a beta-chemokine expressed in the thymus, skin, and intestinal epithelial cells that exclusively binds and activates the CCR6 receptor in both mice and humans. The strict receptor binding specificity of CCL20 is exceptional; other chemokines and their receptors bind promiscuously with multiple partners. Toward determining the structural basis for the selective receptor specificity of CCL20, we have determined its three-dimensional structure by 1H NMR spectroscopy. CCL20 exhibits the same monomeric structure previously described for other chemokines: a three-stranded beta-sheet and an overlying alpha-helix. The CCL20 receptor selectivity could arise from the rigid conformation of the N-terminal DCCL motif as well as the groove between the N-loop and the beta2-beta3 hairpin, which is significantly narrower in CCL20 than in other chemokines. Similar structural features are seen in human beta-defensin 2, a small nonchemokine polypeptide reported to selectively bind and activate CCR6, which stresses their importance for the specific binding of both CCL20 and beta-defensin 2 to CCR6. CCL20's structure will be useful to design tools aimed to modulate its important biological functions.
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===NMR SOLUTION STRUCTURE OF MURINE CCL20/MIP-3A CHEMOKINE===
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NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6.,Perez-Canadillas JM, Zaballos A, Gutierrez J, Varona R, Roncal F, Albar JP, Marquez G, Bruix M J Biol Chem. 2001 Jul 27;276(30):28372-9. Epub 2001 May 23. PMID:11373289<ref>PMID:11373289</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11373289}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ha6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11373289 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11373289}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1HA6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA6 OCA].
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==Reference==
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NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6., Perez-Canadillas JM, Zaballos A, Gutierrez J, Varona R, Roncal F, Albar JP, Marquez G, Bruix M, J Biol Chem. 2001 Jul 27;276(30):28372-9. Epub 2001 May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373289 11373289]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Albar JP]]
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[[Category: Albar, J P.]]
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[[Category: Bruix M]]
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[[Category: Bruix, M.]]
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[[Category: Gutierrez J]]
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[[Category: Gutierrez, J.]]
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[[Category: Marquez G]]
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[[Category: Marquez, G.]]
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[[Category: Perez-Canadillas JM]]
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[[Category: Perez-Canadillas, J M.]]
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[[Category: Roncal F]]
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[[Category: Roncal, F.]]
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[[Category: Varona R]]
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[[Category: Varona, R.]]
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[[Category: Zaballos A]]
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[[Category: Zaballos, A.]]
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[[Category: Ccl20/mip-3a]]
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[[Category: Chemiokine]]
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[[Category: Defensin]]
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[[Category: Mouse]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:53:10 2008''
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Current revision

NMR Solution Structure of Murine CCL20/MIP-3a Chemokine

PDB ID 1ha6

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