1i1j

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(New page: 200px<br /> <applet load="1i1j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i1j, resolution 1.39&Aring;" /> '''STRUCTURE OF MELANO...)
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[[Image:1i1j.gif|left|200px]]<br />
 
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<applet load="1i1j" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1i1j, resolution 1.39&Aring;" />
 
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'''STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS'''<br />
 
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==Overview==
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==STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS==
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Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted, from both chondrocytes and malignant melanoma cells. MIA has been reported, to have effects on cell growth and adhesion, and it may play a role in, melanoma metastasis and cartilage development. We report the 1.4-A crystal, structure of human MIA, which consists of an Src homology 3 (SH3)-like, domain with N- and C-terminal extensions of about 20 aa. each. The N- and, C-terminal extensions add additional structural elements to the SH3, domain, forming a previously undescribed fold. MIA is a representative of, a recently identified family of proteins and is the first structure of a, secreted protein with an SH3 subdomain. The structure also suggests a, likely protein interaction site and suggests that, unlike conventional SH3, domains, MIA does not recognize polyproline helices.
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<StructureSection load='1i1j' size='340' side='right'caption='[[1i1j]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1i1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I1J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1j OCA], [https://pdbe.org/1i1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i1j RCSB], [https://www.ebi.ac.uk/pdbsum/1i1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIA_HUMAN MIA_HUMAN] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/1i1j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i1j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.
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==Disease==
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Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.,Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20. Epub 2001 May 1. PMID:11331761<ref>PMID:11331761</ref>
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Known disease associated with this structure: Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611082 611082]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1I1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA].
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</div>
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<div class="pdbe-citations 1i1j" style="background-color:#fffaf0;"></div>
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==Reference==
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== References ==
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Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins., Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM, Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20. Epub 2001 May 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11331761 11331761]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Alber, T.]]
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[[Category: Alber T]]
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[[Category: Bazan, J.F.]]
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[[Category: Bazan JF]]
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[[Category: Handel, T.M.]]
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[[Category: Handel TM]]
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[[Category: Holton, J.M.]]
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[[Category: Holton JM]]
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[[Category: Lougheed, J.C.]]
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[[Category: Lougheed JC]]
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[[Category: sh3 subdomain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:25:14 2007''
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Current revision

STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS

PDB ID 1i1j

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