1imt

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{{Seed}}
 
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[[Image:1imt.png|left|200px]]
 
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==MAMBA INTESTINAL TOXIN 1, NMR, 39 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1imt", creates the "Structure Box" on the page.
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<StructureSection load='1imt' size='340' side='right'caption='[[1imt]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1imt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IMT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 39 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1imt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imt OCA], [https://pdbe.org/1imt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1imt RCSB], [https://www.ebi.ac.uk/pdbsum/1imt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1imt ProSAT]</span></td></tr>
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{{STRUCTURE_1imt| PDB=1imt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIT1_DENPO MIT1_DENPO] Potently contracts gastrointestinal (GI) smooth muscle. The receptor for this toxin is present both in the CNS and in the smooth muscle and may be a potassium channel.<ref>PMID:10567694</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/1imt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1imt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of mamba intestinal toxin 1 (MIT1), isolated from Dendroaspis polylepis polylepis venom, has been determined. This molecule is a cysteine-rich polypeptide exhibiting no recognised family membership. Resistance to MIT1 to classical specific endoproteases produced contradictory NMR and biochemical information concerning disulphide-bridge topology. We have used distance restraints allowing ambiguous partners between S atoms in combination with NMR-derived structural information, to correctly determine the disulphide-bridge topology. The resultant solution structure of MIT1, determined to a resolution of 0.5 A, reveals an unexpectedly similar global fold with respect to colipase, a protein involved in fatty acid digestion. Colipase exhibits an analogous resistance to endoprotease activity, indicating for the first time the possible topological origins of this biochemical property. The biochemical and structural homology permitted us to propose a mechanically related digestive function for MIT1 and provides novel information concerning snake venom protein evolution.
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===MAMBA INTESTINAL TOXIN 1, NMR, 39 STRUCTURES===
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A structural homologue of colipase in black mamba venom revealed by NMR floating disulphide bridge analysis.,Boisbouvier J, Albrand JP, Blackledge M, Jaquinod M, Schweitz H, Lazdunski M, Marion D J Mol Biol. 1998;283(1):205-19. PMID:9761684<ref>PMID:9761684</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9761684}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1imt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9761684 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9761684}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1IMT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMT OCA].
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==Reference==
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<ref group="xtra">PMID:9761684</ref><references group="xtra"/>
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[[Category: Dendroaspis polylepis polylepis]]
[[Category: Dendroaspis polylepis polylepis]]
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[[Category: Albrand, J P.]]
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[[Category: Large Structures]]
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[[Category: Blackledge, M.]]
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[[Category: Albrand J-P]]
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[[Category: Boisbouvier, J.]]
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[[Category: Blackledge M]]
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[[Category: Jaquinod, M.]]
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[[Category: Boisbouvier J]]
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[[Category: Lazdunski, M.]]
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[[Category: Jaquinod M]]
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[[Category: Marion, D.]]
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[[Category: Lazdunski M]]
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[[Category: Schweitz, H.]]
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[[Category: Marion D]]
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[[Category: Contract guinea pig ileum]]
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[[Category: Schweitz H]]
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[[Category: Resistance to endoprotease]]
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[[Category: Structural homologue of colipase]]
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[[Category: Toxin]]
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[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:02:24 2009''
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Current revision

MAMBA INTESTINAL TOXIN 1, NMR, 39 STRUCTURES

PDB ID 1imt

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