1ip0

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[[Image:1ip0.jpg|left|200px]]<br /><applet load="1ip0" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ip0" />
 
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'''NMR STRUCTURE OF HUMAN BETACELLULIN-2'''<br />
 
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==Overview==
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==NMR STRUCTURE OF HUMAN BETACELLULIN-2==
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The solution structure of the EGF-like domain of betacellulin (BTCe), a, newly discovered member of the epidermal growth factor (EGF) family, has, been determined using two-dimensional nuclear magnetic resonance, spectroscopy. This is the first report to identify the solution structure, of the EGF-family ligand monomers that interact with both ErbB-1 and, ErbB-4. The solution structure of BTCe was calculated using 538, NMR-derived restraints. The overall structure of BTCe was stabilized by, three disulfide bonds, a hydrophobic core, and 23 hydrogen bonds. It, appears that BTCe is comprised of five beta-strands and one short 3(10), helical turn. The secondary structural elements of BTCe are basically, similar to those of the other EGF-family proteins, except that several, significant variations of the structural properties were found. It is, suggested that the structural variations between BTCe and the other, EGF-family ligands may affect the specific receptor-recognition properties, of EGF-family ligands.
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<StructureSection load='1ip0' size='340' side='right'caption='[[1ip0]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ip0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IP0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ip0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ip0 OCA], [https://pdbe.org/1ip0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ip0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ip0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ip0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BTC_HUMAN BTC_HUMAN] Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.<ref>PMID:8570211</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/1ip0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ip0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of the EGF-like domain of betacellulin (BTCe), a newly discovered member of the epidermal growth factor (EGF) family, has been determined using two-dimensional nuclear magnetic resonance spectroscopy. This is the first report to identify the solution structure of the EGF-family ligand monomers that interact with both ErbB-1 and ErbB-4. The solution structure of BTCe was calculated using 538 NMR-derived restraints. The overall structure of BTCe was stabilized by three disulfide bonds, a hydrophobic core, and 23 hydrogen bonds. It appears that BTCe is comprised of five beta-strands and one short 3(10) helical turn. The secondary structural elements of BTCe are basically similar to those of the other EGF-family proteins, except that several significant variations of the structural properties were found. It is suggested that the structural variations between BTCe and the other EGF-family ligands may affect the specific receptor-recognition properties of EGF-family ligands.
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==About this Structure==
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Solution structure of betacellulin, a new member of EGF-family ligands.,Miura K, Doura H, Aizawa T, Tada H, Seno M, Yamada H, Kawano K Biochem Biophys Res Commun. 2002 Jun 28;294(5):1040-6. PMID:12074582<ref>PMID:12074582</ref>
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1IP0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IP0 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of betacellulin, a new member of EGF-family ligands., Miura K, Doura H, Aizawa T, Tada H, Seno M, Yamada H, Kawano K, Biochem Biophys Res Commun. 2002 Jun 28;294(5):1040-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12074582 12074582]
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</div>
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<div class="pdbe-citations 1ip0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aizawa, T.]]
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[[Category: Aizawa T]]
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[[Category: Doura, H.]]
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[[Category: Doura H]]
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[[Category: Kawano, K.]]
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[[Category: Kawano K]]
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[[Category: Miura, K.]]
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[[Category: Miura K]]
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[[Category: Seno, M.]]
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[[Category: Seno M]]
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[[Category: Tada, H.]]
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[[Category: Tada H]]
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[[Category: Yamada, H.]]
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[[Category: Yamada H]]
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[[Category: egf-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:02:47 2008''
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Current revision

NMR STRUCTURE OF HUMAN BETACELLULIN-2

PDB ID 1ip0

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