1ldp

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(New page: 200px<br /> <applet load="1ldp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ldp, resolution 3.1&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1ldp.gif|left|200px]]<br />
 
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<applet load="1ldp" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ldp, resolution 3.1&Aring;" />
 
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'''CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES==
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MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity, alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a, mixture of bound peptides at 3.1 A to construct a model of the allogeneic, 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure., A prominent ridge on the floor of the Ld peptide-binding groove, not, present in Kb, creates a C-terminal bulge in Ld peptides that greatly, increases interactions with the 2C beta-chain. Furthermore, weak, electrostatic complementarity between Asp77 on the alpha1 helix of Kb and, 2C is enhanced in the allogeneic complex by closer proximity of QL9, peptide residue AspP8 to the 2C HV4 loop.
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<StructureSection load='1ldp' size='340' side='right'caption='[[1ldp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ldp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LDP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ldp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ldp OCA], [https://pdbe.org/1ldp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ldp RCSB], [https://www.ebi.ac.uk/pdbsum/1ldp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ldp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE] Involved in the presentation of foreign antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/1ldp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ldp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a mixture of bound peptides at 3.1 A to construct a model of the allogeneic 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure. A prominent ridge on the floor of the Ld peptide-binding groove, not present in Kb, creates a C-terminal bulge in Ld peptides that greatly increases interactions with the 2C beta-chain. Furthermore, weak electrostatic complementarity between Asp77 on the alpha1 helix of Kb and 2C is enhanced in the allogeneic complex by closer proximity of QL9 peptide residue AspP8 to the 2C HV4 loop.
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==About this Structure==
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Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.,Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA Immunity. 1998 May;8(5):553-62. PMID:9620676<ref>PMID:9620676</ref>
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1LDP is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]] and [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with NDG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LDP OCA]].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes., Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 May;8(5):553-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9620676 9620676]
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</div>
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<div class="pdbe-citations 1ldp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Speir JA]]
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[[Category: Speir, J.A.]]
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[[Category: Wilson IA]]
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[[Category: Wilson, I.A.]]
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[[Category: NDG]]
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[[Category: antigen presentation]]
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[[Category: antigen receptor]]
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[[Category: cell surface receptor]]
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[[Category: cellular immunity]]
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[[Category: complex (mhc i/peptide)]]
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[[Category: immunology]]
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[[Category: major histocompatibility complex]]
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[[Category: peptide antigen]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:43:41 2007''
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Current revision

CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES

PDB ID 1ldp

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