1ot0

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[[Image:1ot0.jpg|left|200px]]
 
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==Structure of Antimicrobial Peptide, HP (2-20) and its Analogues Derived from Helicobacter pylori, as Determined by 1H NMR Spectroscopy==
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The line below this paragraph, containing "STRUCTURE_1ot0", creates the "Structure Box" on the page.
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<StructureSection load='1ot0' size='340' side='right'caption='[[1ot0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ot0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OT0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1ot0| PDB=1ot0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ot0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ot0 OCA], [https://pdbe.org/1ot0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ot0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ot0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ot0 ProSAT]</span></td></tr>
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</table>
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'''Structure of Antimicrobial Peptide, HP (2-20) and its Analogues Derived from Helicobacter pylori, as Determined by 1H NMR Spectroscopy'''
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== Function ==
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[https://www.uniprot.org/uniprot/RL1_HELPY RL1_HELPY] Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity).[HAMAP-Rule:MF_01318] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318] Peptides originating from the N-terminal end of L1 have antibacterial activity against bacteria such as E.coli and B.megaterium and modest antifungal activities. Has no effect on H.pylori itself. Peptides are not hemolytic against mammalian cells. These peptides may be released in the stomach during altruistic lysis to kill other fast growing bacteria.[HAMAP-Rule:MF_01318]
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__TOC__
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==About this Structure==
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</StructureSection>
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1OT0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OT0 OCA].
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hahm, K S.]]
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[[Category: Hahm K-S]]
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[[Category: Kim, Y.]]
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[[Category: Kim Y]]
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[[Category: Lee, D G.]]
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[[Category: Lee DG]]
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[[Category: Lee, K H.]]
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[[Category: Lee KH]]
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[[Category: Park, Y.]]
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[[Category: Park Y]]
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[[Category: Antibiotic]]
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[[Category: Coil-helix-coil]]
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[[Category: Ribosomal protein]]
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[[Category: Rrna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:14:52 2008''
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Current revision

Structure of Antimicrobial Peptide, HP (2-20) and its Analogues Derived from Helicobacter pylori, as Determined by 1H NMR Spectroscopy

PDB ID 1ot0

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