1qdp

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[[Image:1qdp.png|left|200px]]
 
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{{STRUCTURE_1qdp| PDB=1qdp | SCENE= }}
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==SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES==
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<StructureSection load='1qdp' size='340' side='right'caption='[[1qdp]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QDP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdp OCA], [https://pdbe.org/1qdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qdp RCSB], [https://www.ebi.ac.uk/pdbsum/1qdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qdp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TXDT1_ATRRO TXDT1_ATRRO] Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels.<ref>PMID:2728033</ref> <ref>PMID:14596608</ref> <ref>PMID:9845331</ref> <ref>PMID:9560455</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/1qdp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qdp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, has been determined from 2D 1H NMR data. Robustoxin is a polypeptide of 42 residues cross-linked by four disulphide bonds, the connectivities of which were determined from NMR data and trial structure calculations to be 1-15, 8-20, 14-31 and 16-42 (a 1-4/2-6/3-7/5-8 pattern). The structure consists of a small three-stranded, anti-parallel beta-sheet and a series of interlocking gamma-turns at the C-terminus. It also contains a cystine knot, thus placing it in the inhibitor cystine knot motif family of structures, which includes the omega-conotoxins and a number of plant and animal toxins and protease inhibitors. Robustoxin contains three distinct charged patches on its surface, and an extended loop that includes several aromatic and non-polar residues. Both of these structural features may play a role in its binding to the voltage-gated sodium channel.
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===SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES===
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Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus.,Pallaghy PK, Alewood D, Alewood PF, Norton RS FEBS Lett. 1997 Dec 15;419(2-3):191-6. PMID:9428632<ref>PMID:9428632</ref>
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{{ABSTRACT_PUBMED_9428632}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1qdp" style="background-color:#fffaf0;"></div>
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[[1qdp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009428632</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Atrax robustus]]
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[[Category: Alewood, D.]]
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[[Category: Alewood, P F.]]
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[[Category: Norton, R S.]]
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[[Category: Pallaghy, P K.]]
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[[Category: Atrax robustus]]
[[Category: Atrax robustus]]
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[[Category: Cystine knot]]
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[[Category: Large Structures]]
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[[Category: Funnel web spider]]
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[[Category: Alewood D]]
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[[Category: Inhibitor cystine knot motif]]
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[[Category: Alewood PF]]
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[[Category: Neurotoxin]]
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[[Category: Norton RS]]
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[[Category: Robustoxin]]
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[[Category: Pallaghy PK]]
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[[Category: Sodium channel modulator]]
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[[Category: Venom]]
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Current revision

SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES

PDB ID 1qdp

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