1uva

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[[Image:1uva.gif|left|200px]]<br />
 
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<applet load="1uva" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1uva, resolution 2.50&Aring;" />
 
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'''LIPID BINDING IN RICE NONSPECIFIC LIPID TRANSFER PROTEIN-1 COMPLEXES FROM ORYZA SATIVA'''<br />
 
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==Overview==
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==Lipid Binding in Rice Nonspecific Lipid Transfer Protein-1 Complexes from Oryza sativa==
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Nonspecific lipid transfer proteins (nsLTPs) facilitate the transfer of, phospholipids, glycolipids, fatty acids and steroids between membranes, with wide-ranging binding affinities. Three crystal structures of rice, nsLTP1 from Oryza sativa, complexed with myristic (MYR), palmitic (PAL) or, stearic acid (STE) were determined. The overall structures of the rice, nsLTP1 complexes belong to the four-helix bundle folding with a long, C-terminal loop. The nsLTP1-MYR and the nsLTP1-STE complexes bind a single, fatty acid while the nsLTP1-PAL complex binds two molecules of fatty, acids. The C-terminal loop region is elastic in order to accommodate a, diverse range of lipid molecules. The lipid molecules interact with the, nsLTP1-binding cavity mainly with hydrophobic interactions. Significant, conformational changes were observed in the binding cavity and the, C-terminal loop of the rice nsLTP1 upon lipid binding.
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<StructureSection load='1uva' size='340' side='right'caption='[[1uva]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1uva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa Oryza sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UVA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uva OCA], [https://pdbe.org/1uva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uva RCSB], [https://www.ebi.ac.uk/pdbsum/1uva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uva ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NLTP1_ORYSJ NLTP1_ORYSJ] Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/1uva_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uva ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nonspecific lipid transfer proteins (nsLTPs) facilitate the transfer of phospholipids, glycolipids, fatty acids and steroids between membranes, with wide-ranging binding affinities. Three crystal structures of rice nsLTP1 from Oryza sativa, complexed with myristic (MYR), palmitic (PAL) or stearic acid (STE) were determined. The overall structures of the rice nsLTP1 complexes belong to the four-helix bundle folding with a long C-terminal loop. The nsLTP1-MYR and the nsLTP1-STE complexes bind a single fatty acid while the nsLTP1-PAL complex binds two molecules of fatty acids. The C-terminal loop region is elastic in order to accommodate a diverse range of lipid molecules. The lipid molecules interact with the nsLTP1-binding cavity mainly with hydrophobic interactions. Significant conformational changes were observed in the binding cavity and the C-terminal loop of the rice nsLTP1 upon lipid binding.
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==About this Structure==
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Lipid binding in rice nonspecific lipid transfer protein-1 complexes from Oryza sativa.,Cheng HC, Cheng PT, Peng P, Lyu PC, Sun YJ Protein Sci. 2004 Sep;13(9):2304-15. Epub 2004 Aug 4. PMID:15295114<ref>PMID:15295114</ref>
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1UVA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryza_sativa Oryza sativa] with MYR as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UVA OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Lipid binding in rice nonspecific lipid transfer protein-1 complexes from Oryza sativa., Cheng HC, Cheng PT, Peng P, Lyu PC, Sun YJ, Protein Sci. 2004 Sep;13(9):2304-15. Epub 2004 Aug 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15295114 15295114]
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</div>
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<div class="pdbe-citations 1uva" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Oryza sativa]]
[[Category: Oryza sativa]]
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[[Category: Single protein]]
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[[Category: Cheng H-C]]
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[[Category: Cheng, H.C.]]
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[[Category: Cheng P-T]]
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[[Category: Cheng, P.T.]]
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[[Category: Lyu P-C]]
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[[Category: Lyu, P.C.]]
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[[Category: Peng P]]
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[[Category: Peng, P.]]
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[[Category: Sun Y-J]]
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[[Category: Sun, Y.J.]]
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[[Category: MYR]]
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[[Category: fatty acid binding]]
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[[Category: lipid transport]]
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[[Category: ltp 1]]
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[[Category: pap 1]]
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[[Category: rice]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 17:12:39 2007''
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Current revision

Lipid Binding in Rice Nonspecific Lipid Transfer Protein-1 Complexes from Oryza sativa

PDB ID 1uva

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