1vj1

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[[Image:1vj1.gif|left|200px]]
 
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{{Structure
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==Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution==
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|PDB= 1vj1 |SIZE=350|CAPTION= <scene name='initialview01'>1vj1</scene>, resolution 2.10&Aring;
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<StructureSection load='1vj1' size='340' side='right'caption='[[1vj1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[1vj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VJ1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= ZADH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2130 COG2130], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00107 ADH_zinc_N]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vj1 OCA], [https://pdbe.org/1vj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vj1 RCSB], [https://www.ebi.ac.uk/pdbsum/1vj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vj1 ProSAT], [https://www.topsan.org/Proteins/JCSG/1vj1 TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vj1 OCA], [http://www.ebi.ac.uk/pdbsum/1vj1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vj1 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PTGR2_MOUSE PTGR2_MOUSE] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.<ref>PMID:17449869</ref>
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== Evolutionary Conservation ==
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'''Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/1vj1_consurf.spt"</scriptWhenChecked>
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1VJ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ1 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution., Levin I, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Biorac T, Cambell J, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hampton E, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, McPhillips TM, Miller MD, Morse A, Moy K, Ouyang J, Page R, Quijano K, Reyes R, Robb A, Sims E, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, von Delft F, Wang X, West B, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA, Proteins. 2004 Aug 15;56(3):629-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15229897 15229897]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vj1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
 
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[[Category: JCSG, Joint Center for Structural Genomics.]]
 
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[[Category: jcsg]]
 
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[[Category: joint center for structural genomic]]
 
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[[Category: protein structure initiative]]
 
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[[Category: psi]]
 
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[[Category: putative nadph-dependent oxidoreductase]]
 
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[[Category: structural genomic]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:25:09 2008''
 

Current revision

Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution

PDB ID 1vj1

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