1vj1

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(New page: 200px<br /><applet load="1vj1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vj1, resolution 2.10&Aring;" /> '''Crystal structure of...)
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[[Image:1vj1.gif|left|200px]]<br /><applet load="1vj1" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1vj1, resolution 2.10&Aring;" />
 
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'''Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution==
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1VJ1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VJ1 OCA].
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<StructureSection load='1vj1' size='340' side='right'caption='[[1vj1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[1vj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VJ1 FirstGlance]. <br>
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Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution., Levin I, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Biorac T, Cambell J, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hampton E, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, McPhillips TM, Miller MD, Morse A, Moy K, Ouyang J, Page R, Quijano K, Reyes R, Robb A, Sims E, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, von Delft F, Wang X, West B, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA, Proteins. 2004 Aug 15;56(3):629-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15229897 15229897]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vj1 OCA], [https://pdbe.org/1vj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vj1 RCSB], [https://www.ebi.ac.uk/pdbsum/1vj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vj1 ProSAT], [https://www.topsan.org/Proteins/JCSG/1vj1 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGR2_MOUSE PTGR2_MOUSE] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.<ref>PMID:17449869</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/1vj1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vj1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
 
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[[Category: JCSG, Joint.Center.for.Structural.Genomics.]]
 
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[[Category: jcsg]]
 
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[[Category: joint center for structural genomics]]
 
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[[Category: protein structure initiative]]
 
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[[Category: psi]]
 
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[[Category: putative nadph-dependent oxidoreductase]]
 
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[[Category: structural genomics]]
 
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:53:51 2007''
 

Current revision

Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution

PDB ID 1vj1

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