2hhi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (01:01, 21 November 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2hhi.png|left|200px]]
 
-
<!--
+
==The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a novel class of beta-grasp proteins==
-
The line below this paragraph, containing "STRUCTURE_2hhi", creates the "Structure Box" on the page.
+
<StructureSection load='2hhi' size='340' side='right'caption='[[2hhi]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2hhi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HHI FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 24 models</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hhi OCA], [https://pdbe.org/2hhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hhi RCSB], [https://www.ebi.ac.uk/pdbsum/2hhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hhi ProSAT]</span></td></tr>
-
{{STRUCTURE_2hhi| PDB=2hhi | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MP64_MYCTU MP64_MYCTU]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/2hhi_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hhi ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The MPT64 protein and its homologs form a highly conserved family of secreted proteins with unknown function that are found within the pathogenic Mycobacteria genus. The founding member of this family from Mycobacterium tuberculosis (MPT64 or protein Rv1980c) is expressed only when Mycobacteria cells are actively dividing. By virtue of this relatively unique expression profile, Rv1980c is currently under phase III clinical trials to evaluate its potential to replace tuberculin, or purified protein derivative, as the rapid diagnostic of choice for detection of active tuberculosis infection. We describe here the NMR solution structure of Rv1980c. This structure reveals a previously undescribed fold that is based upon a variation of a beta-grasp motif most commonly found in protein-protein interaction domains. Examination of this structure in conjunction with multiple sequence alignments of MPT64 homologs identifies a candidate ligand-binding site, which may help guide future studies of Rv1980c function. The work presented here also suggests structure-based approaches for increasing the antigenic potency of a Rv1980c-based diagnostic.
-
===The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a novel class of beta-grasp proteins===
+
The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins.,Wang Z, Potter BM, Gray AM, Sacksteder KA, Geisbrecht BV, Laity JH J Mol Biol. 2007 Feb 16;366(2):375-81. Epub 2006 Nov 14. PMID:17174329<ref>PMID:17174329</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17174329}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2hhi" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17174329 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17174329}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2HHI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHI OCA].
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
 
+
[[Category: Geisbrecht BV]]
-
==Reference==
+
[[Category: Gray AM]]
-
The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins., Wang Z, Potter BM, Gray AM, Sacksteder KA, Geisbrecht BV, Laity JH, J Mol Biol. 2007 Feb 16;366(2):375-81. Epub 2006 Nov 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17174329 17174329]
+
[[Category: Laity JH]]
-
[[Category: Mycobacterium tuberculosis]]
+
[[Category: Potter BM]]
-
[[Category: Single protein]]
+
[[Category: Sacksteder KA]]
-
[[Category: Geisbrecht, B V.]]
+
[[Category: Wang Z]]
-
[[Category: Gray, A M.]]
+
-
[[Category: Laity, J H.]]
+
-
[[Category: Potter, B M.]]
+
-
[[Category: Sacksteder, K A.]]
+
-
[[Category: Wang, Z.]]
+
-
[[Category: Beta-grasp]]
+
-
[[Category: Mpt64]]
+
-
[[Category: Nmr solution structure]]
+
-
[[Category: Residual dipolar coupling]]
+
-
[[Category: Secreted antigen]]
+
-
[[Category: Tuberculosis]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:52:12 2008''
+

Current revision

The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a novel class of beta-grasp proteins

PDB ID 2hhi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools