2jjb

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{{Seed}}
 
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[[Image:2jjb.png|left|200px]]
 
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==Family 37 trehalase from Escherichia coli in complex with casuarine-6- O-alpha-glucopyranose==
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The line below this paragraph, containing "STRUCTURE_2jjb", creates the "Structure Box" on the page.
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<StructureSection load='2jjb' size='340' side='right'caption='[[2jjb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jjb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3CU:CASUARINE'>3CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2jjb| PDB=2jjb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjb OCA], [https://pdbe.org/2jjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjb RCSB], [https://www.ebi.ac.uk/pdbsum/2jjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TREA_ECOLI TREA_ECOLI] Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.[HAMAP-Rule:MF_01060]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jjb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Total synthesis of naturally occurring casuarine (1) and the first total synthesis of casuarine 6-O-alpha-glucoside (2) were achieved through complete stereoselective nitrone cycloaddition, Tamao-Fleming oxidation and selective alpha-glucosylation as key steps. Biological assays of the two compounds proved their strong and selective inhibitory properties towards glucoamylase NtMGAM and trehalase Tre37A, respectively, which place them among the most powerful inhibitors of these enzymes. The structural determination of the complexes of NtMGAM with 1 and of Tre37A with 2 revealed interesting similarities in the catalytic sites of these two enzymes which belong to different families and clans.
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===FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH CASUARINE-6-O-ALPHA-GLUCOPYRANOSE===
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Total Syntheses of Casuarine and Its 6-O-alpha-Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families.,Cardona F, Parmeggiani C, Faggi E, Bonaccini C, Gratteri P, Sim L, Gloster TM, Roberts S, Davies GJ, Rose DR, Goti A Chemistry. 2009 Jan 2. PMID:19123216<ref>PMID:19123216</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19123216}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jjb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19123216 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19123216}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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2JJB is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJB OCA].
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[[Category: Large Structures]]
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[[Category: Bonaccini C]]
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==Reference==
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[[Category: Cardona F]]
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<ref group="xtra">PMID:19123216</ref><references group="xtra"/>
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[[Category: Davies GJ]]
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[[Category: Alpha,alpha-trehalase]]
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[[Category: Gloster TM]]
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[[Category: Escherichia coli]]
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[[Category: Goti A]]
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[[Category: Bonaccini, C.]]
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[[Category: Gratteri P]]
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[[Category: Cardona, F.]]
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[[Category: Parmeggiani C]]
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[[Category: Davies, G J.]]
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[[Category: Roberts S]]
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[[Category: Gloster, T M.]]
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[[Category: Rose DR]]
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[[Category: Goti, A.]]
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[[Category: Sim L]]
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[[Category: Gratteri, P.]]
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[[Category: Parmeggiani, C.]]
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[[Category: Roberts, S.]]
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[[Category: Rose, D R.]]
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[[Category: Sim, L.]]
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[[Category: Glycosidase]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 08:43:41 2010''
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Current revision

Family 37 trehalase from Escherichia coli in complex with casuarine-6- O-alpha-glucopyranose

PDB ID 2jjb

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