2psr

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[[Image:2psr.gif|left|200px]]<br /><applet load="2psr" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2psr, resolution 2.05&Aring;" />
 
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'''HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)'''<br />
 
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==Overview==
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==HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)==
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The crystal structure of human psoriasin (S100A7) in the native, calcium-bound form has been determined from two crystal forms of the, protein crystallized with and without divalent zinc. The overall, structures of the dimeric protein closely resemble the previously, determined holmium-substituted structure. The structures also reveal a, zinc-binding site of the protein, which is formed by three histidines and, an aspartate residue. Together, these residues coordinate the zinc ion in, a way similar to the pattern seen in certain metalloproteases and in, particular the collagenase family of proteins. Sequence comparison, suggests that this zinc site is present in a number of the remaining, members of the S100 family. The structure of S100A7 crystallized in the, absence of zinc further shows that loss of zinc results in a, reorganization of the adjacent empty and distorted EF-hand loop, causing, it to resemble a calcium-loaded EF-hand.
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<StructureSection load='2psr' size='340' side='right'caption='[[2psr]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2psr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PSR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2psr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2psr OCA], [https://pdbe.org/2psr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2psr RCSB], [https://www.ebi.ac.uk/pdbsum/2psr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2psr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S10A7_HUMAN S10A7_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/2psr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2psr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of human psoriasin (S100A7) in the native, calcium-bound form has been determined from two crystal forms of the protein crystallized with and without divalent zinc. The overall structures of the dimeric protein closely resemble the previously determined holmium-substituted structure. The structures also reveal a zinc-binding site of the protein, which is formed by three histidines and an aspartate residue. Together, these residues coordinate the zinc ion in a way similar to the pattern seen in certain metalloproteases and in particular the collagenase family of proteins. Sequence comparison suggests that this zinc site is present in a number of the remaining members of the S100 family. The structure of S100A7 crystallized in the absence of zinc further shows that loss of zinc results in a reorganization of the adjacent empty and distorted EF-hand loop, causing it to resemble a calcium-loaded EF-hand.
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==About this Structure==
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Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.,Brodersen DE, Nyborg J, Kjeldgaard M Biochemistry. 1999 Feb 9;38(6):1695-704. PMID:10026247<ref>PMID:10026247</ref>
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2PSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=CAA:Regulatory+Ca2++Binding+Site'>CAA</scene> and <scene name='pdbsite=ZNA:Zn2++Binding+Site'>ZNA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSR OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states., Brodersen DE, Nyborg J, Kjeldgaard M, Biochemistry. 1999 Feb 9;38(6):1695-704. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10026247 10026247]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 2psr" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Brodersen, D.E.]]
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[[Category: Kjeldgaard, M.]]
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[[Category: Nyborg, J.]]
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[[Category: CA]]
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[[Category: ZN]]
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[[Category: ca-binding]]
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[[Category: ef-hand protein]]
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[[Category: psoriasis]]
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[[Category: s100 protein family]]
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[[Category: zn-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:46:41 2008''
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Brodersen DE]]
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[[Category: Kjeldgaard M]]
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[[Category: Nyborg J]]

Current revision

HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)

PDB ID 2psr

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