3fct

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{{Seed}}
 
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[[Image:3fct.png|left|200px]]
 
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==MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN==
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The line below this paragraph, containing "STRUCTURE_3fct", creates the "Structure Box" on the page.
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<StructureSection load='3fct' size='340' side='right'caption='[[3fct]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fct]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FCT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MMP:N-METHYLMESOPORPHYRIN'>MMP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_3fct| PDB=3fct | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fct OCA], [https://pdbe.org/3fct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fct RCSB], [https://www.ebi.ac.uk/pdbsum/3fct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fct ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/3fct_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fct ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A classic hypothesis for enzyme catalysis is the induction of strain in the substrate. This notion was first expressed by Haldane with the lock and key analogy-"the key does not fit the lock perfectly but exercises a certain strain on it" (1). This mechanism has often been invoked to explain the catalytic efficiency of enzymes but has been difficult to establish conclusively (2-7). Here we describe X-ray crystallographic and mutational studies of an antibody metal chelatase which strongly support the notion that this antibody catalyzes metal ion insertion into the porphyrin ring by inducing strain. Analysis of the germline precursor suggests that this strain mechanism arose during the process of affinity maturation in response to a conformationally distorted N-alkylmesoporphyrin.
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===MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN===
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Structural and kinetic evidence for strain in biological catalysis.,Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC Biochemistry. 1998 Oct 13;37(41):14404-9. PMID:9772166<ref>PMID:9772166</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3fct" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9772166}}, adds the Publication Abstract to the page
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9772166 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9772166}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FCT OCA].
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[[Category: Large Structures]]
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[[Category: Barnes D]]
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==Reference==
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[[Category: Romesberg FE]]
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Structural and kinetic evidence for strain in biological catalysis., Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC, Biochemistry. 1998 Oct 13;37(41):14404-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9772166 9772166]
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[[Category: Santarsiero BD]]
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[[Category: Barnes, D.]]
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[[Category: Schultz PG]]
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[[Category: Romesberg, F E.]]
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[[Category: Spiller B]]
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[[Category: Santarsiero, B D.]]
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[[Category: Stevens RC]]
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[[Category: Schultz, P G.]]
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[[Category: Yin J]]
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[[Category: Spiller, B.]]
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[[Category: Stevens, R C.]]
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[[Category: Yin, J.]]
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[[Category: Catalytic antibody]]
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[[Category: Fab fragment]]
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[[Category: Metal chelatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:02:14 2008''
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Current revision

MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN

PDB ID 3fct

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