3hke

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==Tubulin-T138067: RB3 stathmin-like domain complex==
==Tubulin-T138067: RB3 stathmin-like domain complex==
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<StructureSection load='3hke' size='340' side='right' caption='[[3hke]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<StructureSection load='3hke' size='340' side='right'caption='[[3hke]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sa0|1sa0]], [[1sa1|1sa1]], [[3hkb|3hkb]], [[3hkc|3hkc]], [[3hkd|3hkd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [https://pdbe.org/3hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [https://www.ebi.ac.uk/pdbsum/3hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hke ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://pdbe.org/3hke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>
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[https://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hke_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hke_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Stathmin|Stathmin]]
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*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
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*[[Tubulin|Tubulin]]
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
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[[Category: Dorleans, A]]
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[[Category: Rattus norvegicus]]
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[[Category: Gigant, B]]
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[[Category: Dorleans A]]
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[[Category: Knossow, M]]
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[[Category: Gigant B]]
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[[Category: Mailliet, P]]
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[[Category: Knossow M]]
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[[Category: Mikol, V]]
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[[Category: Mailliet P]]
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[[Category: Ravelli, R B.G]]
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[[Category: Mikol V]]
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[[Category: Alpha-tubulin]]
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[[Category: Ravelli RBG]]
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[[Category: Beta-tubulin]]
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[[Category: Cell cycle]]
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[[Category: Colchicine domain]]
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[[Category: Covalent binding]]
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[[Category: Gtpase]]
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[[Category: Microtubule]]
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[[Category: Stathmin]]
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[[Category: Tubulin]]
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Current revision

Tubulin-T138067: RB3 stathmin-like domain complex

PDB ID 3hke

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